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EBI PDBe PDBeView

PDBe Entry: 1k4h view

CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COMPLEXED WITH 2,6-Diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 19.6%, Free R-factor: 22.9%, Spacegroup: C 1 2 1
Released 24/04/2002, deposition: 08/10/2001, last revision: 24/02/2009
Authors Brenk, R.search; Meyer, E.A.search; Castellano, R.K.search; Furler, M.search; Stubbs, M.T.search; Klebe, G.search; Diederich, F.search
Primary citation De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity.
CHEMBIOCHEMsearch vol:3, pag:250-253 (2002) [PubMed ID 11921407 ]search
Keywords TRNA-MODIFYING ENZYMEsearch, GLYCOSYLTRANSFERASEsearch
EC 2.4.2.29 ExPASy BRENDA search (A)
Organism Zymomonas mobilis 542search(A)
UniProt Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (tRNA-guanine transglycosylase) (Guanine insertion enzyme) P28720search (A)
Solvent A
Related entries 1enu, 1pud, 1f3e, 1k4g
Polymers
Id Name Type UniProt Residues Observed
A TRNA-GUANINE-TRANSGLYCOYLASE Protein P28720 (TGT_ZYMMO)search
 386 96%
Heterogens
Id Name Ligands
A ZINC ION ZN search
A 2,6-DIAMINO-8-PROPYLSULFANYLMETHYL-3H-QUINAZOLINE-4-ONE APQ search
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