1k4c Summary

pdbe.org/1k4c
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Potassium Channel KcsA-Fab complex in high concentration of K+

The structure was published by Zhou, Y., Morais-Cabral, J.H., Kaufman, A., and MacKinnon, R., in 2001 in a paper entitled "Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely antibody Fab fragment heavy chain, antibody Fab fragment light chain, and potassium channel KcsA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A antibody Fab fragment heavy chain Not available
Mus musculussearch Not available 219 100%
B antibody Fab fragment light chain Not available
Mus musculussearch Not available 212 100%
C potassium channel KcsA P0A334 (1-124) (KCSA_STRLI)search Streptomyces lividanssearch 100% 124 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A334 (1 - 124) potassium channel KcsA Streptomyces lividans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
B V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
C (P0A334) Voltage-gated potassium channelssearch Helix Hairpinssearch PF07885: Ion channelsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
C (P0A334) voltage-gated potassium channel complexsearch potassium ion transportsearch voltage-gated potassium channel activitysearch

Chain InterPro annotation
A Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C Potassium channelsearch Two pore domain potassium channel domainsearch Voltage-gated potassium channelsearch