1k3a Summary


Structure of the Insulin-like Growth Factor 1 Receptor Kinase

The structure was published by Favelyukis, S., Till, J.H., Hubbard, S.R., and Miller, W.T., in 2001 in a paper entitled "Structure and autoregulation of the insulin-like growth factor 1 receptor kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely insulin-like growth factor 1 receptor and insulin receptor substrate 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A insulin-like growth factor 1 receptor P08069 (988-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 299 97%
B insulin receptor substrate 1 P35568 (891-902) (IRS1_HUMAN)search Homo sapienssearch < 90% 14 57%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P08069 (988 - 1286) insulin-like growth factor 1 receptor Homo sapiens
P35568 (891 - 902) insulin receptor substrate 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P08069) transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch regulation of signal transductionsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch