1k2d

X-ray diffraction
2.2Å resolution

Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-136046 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class II histocompatibility antigen, A-U alpha chain Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.47 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P14438 (Residues: 1-179; Coverage: 79%)
Gene name: H2-Aa
Sequence domains:
Structure domains:
H-2 class II histocompatibility antigen, A-U beta chain Chain: B
Molecule details ›
Chain: B
Length: 189 amino acids
Theoretical weight: 22.5 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P06344 (Residues: 28-216; Coverage: 80%)
Sequence domains:
Structure domains:
Myelin basic protein Chain: P
Molecule details ›
Chain: P
Length: 23 amino acids
Theoretical weight: 2.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02686 (Residues: 134-144; Coverage: 4%)
Gene name: MBP

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2221
Unit cell:
a: 99.15Å b: 110.59Å c: 94.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.248 0.276
Expression systems:
  • Drosophila melanogaster
  • Not provided