1k25 Summary

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PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate

The structure was published by Dessen, A., Mouz, N., Gordon, E., Hopkins, J., and Dideberg, O., in 2001 in a paper entitled "Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of low-affinity PENICILLIN-BINDING PROTEIN 2X.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A low-affinity PENICILLIN-BINDING PROTEIN 2X O34006 (66-750) (O34006_STREE)search Streptococcus pneumoniaesearch 91% 685 83%
B low-affinity PENICILLIN-BINDING PROTEIN 2X O34006 (66-750) (O34006_STREE)search Streptococcus pneumoniaesearch 91% 685 83%
C low-affinity PENICILLIN-BINDING PROTEIN 2X O34006 (66-750) (O34006_STREE)search Streptococcus pneumoniaesearch 91% 685 83%
D low-affinity PENICILLIN-BINDING PROTEIN 2X O34006 (66-750) (O34006_STREE)search Streptococcus pneumoniaesearch 91% 685 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O34006 (66 - 750) low-affinity PENICILLIN-BINDING PROTEIN 2X Streptococcus pneumoniae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Penicillin-binding protein 2x (pbp-2x), c-terminal domainsearch, Penicillin binding protein dimerisation domainsearch, beta-Lactamase/D-ala carboxypeptidasesearch DD-peptidase/beta-lactamase superfamilysearch Penicillin binding protein transpeptidase domainsearch, Penicillin-binding Protein dimerisation domainsearch, PASTA domainsearch

Chain ID Molecular function (GO)
A, B, C, D (O34006) penicillin bindingsearch

Chain InterPro annotation
A, B, C, D Penicillin-binding protein, transpeptidasesearch Penicillin-binding protein, dimerisation domainsearch PASTA domainsearch Beta-lactamase/transpeptidase-likesearch