1k1k Summary

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Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer.

The structure was published by Dewan, J.C., Feeling-Taylor, A., Puius, Y.A., et al., Nagel, R.L., Almo, S.C., and Hirsch, R.E., in 2002 in a paper entitled "Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch oxygen transportsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B (P68871) haptoglobin bindingsearch metal ion bindingsearch protein bindingsearch hemoglobin bindingsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch hemoglobin complexsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch oxygen transportsearch blood coagulationsearch response to hydrogen peroxidesearch platelet aggregationsearch regulation of blood vessel sizesearch transportsearch bicarbonate transportsearch regulation of blood pressuresearch small molecule metabolic processsearch nitric oxide transportsearch renal absorptionsearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch