1k1k Summary

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Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer.

The structure was published by Dewan, J.C., Feeling-Taylor, A., Puius, Y.A., et al., Nagel, R.L., Almo, S.C., and Hirsch, R.E., in 2002 in a paper entitled "Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein heterooligomerizationsearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch oxygen transportsearch transportsearch oxidation-reduction processsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch
B (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch hemoglobin bindingsearch heme bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch renal absorptionsearch small molecule metabolic processsearch regulation of blood vessel sizesearch oxidation-reduction processsearch nitric oxide transportsearch platelet aggregationsearch blood coagulationsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch regulation of blood pressuresearch response to hydrogen peroxidesearch protein heterooligomerizationsearch transportsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch