spacer
EBI PDBe PDBeView

PDBe Entry: 1k0u view

Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 23.1%, Free R-factor: 26.5%, Spacegroup: P 1 21 1
Released 17/10/2001, deposition: 20/09/2001, last revision: 24/02/2009
Authors Takusagawa, F.search; Huang, Y.search; Komoto, J.search; Takata, Y.search; Gomi, T.search; Ogawa, H.search; Fujioka, M.search; Powell, D.search
Primary citation Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.BIOL.CHEM.search vol:277, pag:7477-7482 (2002) [PubMed ID 11741948 ]search
Keywords S-adenosylhomocysteinesearch, hydrolasesearch, D-eritadeninesearch, inhibitorsearch
EC 3.3.1.1 ExPASy BRENDA search (A B C D E F G H)
Organism Rattus norvegicus(Norway rat) 10116search(A B C D E F G H)
UniProt Adenosylhomocysteinase (EC 3.3.1.1) (AdoHcyase) (S-adenosyl-L-homocysteine hydrolase) P10760search (A B C D E F G H)
Solvent A, B, C, D, E, F, G, H
Related entries 1d4g
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D, E, F, G, H S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE Protein P10760 (SAHH_RAT)search
 431 99%
Heterogens
Id Name Ligands
A, B, C, D, E, F, G, H NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD search
A, B, C, D, E, F, G, H D-ERITADENINE DEA search
spacer