1k04 Summary


Crystal Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase

The structure was published by Arold, S.T., Hoellerer, M.K., and Noble, M.E., in 2002 in a paper entitled "The structural basis of localization and signaling by the focal adhesion targeting domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of FOCAL ADHESION KINASE 1. This molecule has the UniProt identifier Q05397 (FAK1_HUMAN)search. The sample contained 162 residues which is < 90% of the natural sequence. Out of 162 residues 142 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FOCAL ADHESION KINASE 1 Q05397 (891-1052) (FAK1_HUMAN)search Homo sapienssearch < 90% 162 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05397 (891 - 1052) FOCAL ADHESION KINASE 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A FAT domain of focal adhesion kinasesearch Single helix binsearch, Nucleotidyltransferases domain 2search Focal adhesion targeting regionsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q05397) protein phosphorylationsearch signal complex assemblysearch signal transducer activitysearch protein tyrosine kinase activitysearch focal adhesionsearch

Chain InterPro annotation
A Focal adhesion kinase, targeting (FAT) domainsearch