1jy7 Summary

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THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME

The structure was published by Biswal, B.K. and Vijayan, M., in 2002 in a paper entitled "Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
P Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
R Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
U Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
W Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
Q Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
S Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
V Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
X Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, P, R, U, W (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, Q, S, V, X (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C, P, R, U, W (P69905) hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxygen transportsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch
B, D, Q, S, V, X (P68871) hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen transportsearch renal absorptionsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch regulation of blood pressuresearch protein heterooligomerizationsearch nitric oxide transportsearch platelet aggregationsearch regulation of blood vessel sizesearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch transportsearch hydrogen peroxide catabolic processsearch blood coagulationsearch

Chain InterPro annotation
A, C, P, R, U, W Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, Q, S, V, X Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch