1jwh Summary


Crystal Structure of Human Protein Kinase CK2 Holoenzyme

The structure was published by Niefind, K., Guerra, B., Ermakowa, I., and Issinger, O.G., in 2001 in a paper entitled "Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Casein kinase II, alpha chain and Casein kinase II beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Casein kinase II, alpha chain P68400 (1-337) (CSK21_HUMAN)search Homo sapienssearch 100% 337 99%
B Casein kinase II, alpha chain P68400 (1-337) (CSK21_HUMAN)search Homo sapienssearch 100% 337 99%
C Casein kinase II beta chain P67870 (1-215) (CSK2B_HUMAN)search Homo sapienssearch 90% 215 94%
D Casein kinase II beta chain P67870 (1-215) (CSK2B_HUMAN)search Homo sapienssearch 90% 215 94%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P68400 (1 - 337) Casein kinase II, alpha chain Homo sapiens
P67870 (1 - 215) Casein kinase II beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P68400) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
C, D (P67870) Casein kinase II beta subunitsearch protein kinase ck2 holoenzyme, chain C, domain 1search, N-terminal domain of TfIIbsearch PF01214: Casein kinase II regulatory subunitsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P68400) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch
C, D (P67870) protein kinase regulator activitysearch protein bindingsearch receptor bindingsearch identical protein bindingsearch transcription factor bindingsearch protein domain specific bindingsearch protein serine/threonine kinase activitysearch metal ion bindingsearch negative regulation of cell proliferationsearch regulation of DNA bindingsearch regulation of protein kinase activitysearch endothelial tube morphogenesissearch positive regulation of pathway-restricted SMAD protein phosphorylationsearch mitotic cell cyclesearch axon guidancesearch signal transductionsearch protein phosphorylationsearch adiponectin-activated signaling pathwaysearch cellular protein complex assemblysearch Wnt signaling pathwaysearch negative regulation of blood vessel endothelial cell migrationsearch positive regulation of activin receptor signaling pathwaysearch protein kinase CK2 complexsearch cytoplasmsearch cytosolsearch PcG protein complexsearch extracellular vesicular exosomesearch nucleussearch plasma membranesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
C, D Casein kinase II, regulatory subunitsearch Casein kinase II, regulatory subunit, alpha-helicalsearch Casein kinase II, regulatory subunit, beta-sheetsearch