1jsv Summary


The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

The structure was published by Clare, P.M., Poorman, R.A., Kelley, L.C., Watenpaugh, K.D., Bannow, C.A., and Leach, K.L., in 2001 in a paper entitled "The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.96 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 287 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch metal ion bindingsearch kinase activitysearch nucleotide bindingsearch histone kinase activitysearch transferase activitysearch cyclin bindingsearch protein phosphorylationsearch potassium ion transportsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic G2 phasesearch phosphorylationsearch G2/M transition of mitotic cell cyclesearch histone phosphorylationsearch centrosome duplicationsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic cell cyclesearch cell cyclesearch blood coagulationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G1 DNA damage checkpointsearch DNA repairsearch mitotic nuclear divisionsearch DNA replicationsearch Ras protein signal transductionsearch cellular response to nitric oxidesearch positive regulation of transcription, DNA-templatedsearch cell divisionsearch G1/S transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch positive regulation of cell proliferationsearch meiotic nuclear divisionsearch regulation of gene silencingsearch nucleoplasmsearch endosomesearch transcription factor complexsearch microtubule organizing centersearch cytoplasmsearch cytosolsearch centrosomesearch chromosome, telomeric regionsearch nucleussearch Y chromosomesearch cytoskeletonsearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch Cajal bodysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch