1jsu Summary

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P27(KIP1)/CYCLIN A/CDK2 COMPLEX

The structure was published by Russo, A.A., Jeffrey, P.D., Patten, A.K., Massague, J., and Pavletich, N.P., in 1996 in a paper entitled "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CYCLIN-DEPENDENT KINASE-2, CYCLIN A, and P27.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE-2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 95%
B CYCLIN A P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
C P27 P46527 (23-106) (CDN1B_HUMAN)search Homo sapienssearch < 90% 84 82%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT KINASE-2 Homo sapiens
P20248 (173 - 432) CYCLIN A Homo sapiens
P46527 (23 - 106) P27 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch
C P27(KIP1) fragment 22-106search p27search Cyclin-dependent kinase inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch histone kinase activitysearch nucleotide bindingsearch kinase activitysearch cyclin bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch meiotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of DNA-dependent DNA replication initiationsearch meiotic nuclear divisionsearch blood coagulationsearch mitotic cell cyclesearch cell cyclesearch cellular response to DNA damage stimulussearch centrosome duplicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch Ras protein signal transductionsearch G1/S transition of mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch DNA repairsearch positive regulation of cell proliferationsearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch cell divisionsearch cellular response to nitric oxidesearch DNA replicationsearch mitotic nuclear divisionsearch regulation of gene silencingsearch histone phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch peptidyl-serine phosphorylationsearch nucleoplasmsearch X chromosomesearch cytoskeletonsearch endosomesearch cytosolsearch nucleussearch microtubule organizing centersearch Cajal bodysearch transcription factor complexsearch centrosomesearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch condensed chromosomesearch cytoplasmsearch Y chromosomesearch
B (P20248) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch nucleussearch
C (P46527) cyclin-dependent protein serine/threonine kinase inhibitor activitysearch regulation of cell proliferationsearch cell cycle arrestsearch nucleussearch cytoplasmsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch
C Cyclin-dependent kinase inhibitorsearch Cyclin-dependent kinase inhibitor 1Bsearch