1jst Summary



The structure was published by Russo, A.A., Jeffrey, P.D., and Pavletich, N.P., in 1996 in a paper entitled "Structural basis of cyclin-dependent kinase activation by phosphorylation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CYCLIN-DEPENDENT KINASE-2 and CYCLIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE-2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 100%
C CYCLIN-DEPENDENT KINASE-2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 100%
B CYCLIN A P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT KINASE-2 Homo sapiens
P20248 (175 - 432) CYCLIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch histone kinase activitysearch metal ion bindingsearch kinase activitysearch protein phosphorylationsearch cell divisionsearch potassium ion transportsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G2/M transition of mitotic cell cyclesearch blood coagulationsearch DNA replicationsearch regulation of gene silencingsearch histone phosphorylationsearch mitotic G1 DNA damage checkpointsearch G1/S transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic nuclear divisionsearch phosphorylationsearch mitotic cell cyclesearch Ras protein signal transductionsearch meiotic nuclear divisionsearch cell cyclesearch positive regulation of transcription, DNA-templatedsearch positive regulation of DNA-dependent DNA replication initiationsearch centrosome duplicationsearch positive regulation of cell proliferationsearch DNA repairsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to nitric oxidesearch nucleussearch nucleoplasmsearch X chromosomesearch cytoplasmsearch microtubule organizing centersearch cytosolsearch endosomesearch Cajal bodysearch centrosomesearch transcription factor complexsearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch Y chromosomesearch condensed chromosomesearch cytoskeletonsearch
B, D (P20248) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch