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PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A

X-ray diffraction
2.6Å resolution
PDB entry 1jst coloured by chain, front view.
PDB entry 1jst coloured by chain, side view.
PDB entry 1jst coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Cyclin-A2 and Cyclin-dependent kinase 2
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Multimeric state: hetero tetramer
Accessible surface area: 42632.34 Å2
Buried surface area: 10388.43 Å2
Dissociation area: 952.2 Å2
Dissociation energy (ΔGdiss): -7.03 kcal/mol
Dissociation entropy (TΔSdiss): 14.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148908
Assembly 2 (preferred)
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Assembly Name: Cyclin A2-CDK2 complex
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Multimeric state: hetero dimer
Accessible surface area: 22212.88 Å2
Buried surface area: 4286.15 Å2
Dissociation area: 1,643.11 Å2
Dissociation energy (ΔGdiss): 14.17 kcal/mol
Dissociation entropy (TΔSdiss): 13.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148886
Complex Portal ID: CPX-2006
Assembly 3
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Assembly Name: Cyclin A2-CDK2 complex
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Multimeric state: hetero dimer
Accessible surface area: 22323.86 Å2
Buried surface area: 4197.88 Å2
Dissociation area: 1,602.07 Å2
Dissociation energy (ΔGdiss): 13.97 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148886
Complex Portal ID: CPX-2006

Macromolecules

Cyclin-dependent kinase 2
Chains: A, C
Length: 298 amino acids
Theoretical weight: 34.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 1jst, assembly 2, front view.
Cyclin-dependent kinase 2 in PDB entry 1jst, assembly 2, side view.
Cyclin-dependent kinase 2 in PDB entry 1jst, assembly 2, top view.
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Cyclin-A2
Chains: B, D
Length: 258 amino acids
Theoretical weight: 29.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20248 (Residues: 175-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-A2 in PDB entry 1jst, assembly 2, front view.
Cyclin-A2 in PDB entry 1jst, assembly 2, side view.
Cyclin-A2 in PDB entry 1jst, assembly 2, top view.
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