1jr4 Summary



The structure was published by Lerner, C., Ruf, A., Gramlich, V., et al., Jakob-Roetne, R., Borroni, E., and Diederich, F., in 2001 in a paper entitled "X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.63 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM. This molecule has the UniProt identifier P22734 (COMT_RAT)search. The sample contained 221 residues which is < 90% of the natural sequence. Out of 221 residues 212 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM P22734 (44-264) (COMT_RAT)search Rattus norvegicussearch < 90% 221 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22734 (44 - 264) CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A COMT-likesearch Vaccinia Virus protein VP39search O-methyltransferasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P22734) neurotransmitter catabolic processsearch catecholamine metabolic processsearch magnesium ion bindingsearch catechol O-methyltransferase activitysearch O-methyltransferase activitysearch

Chain InterPro annotation
A O-methyltransferase, family 3search Catechol O-methyltransferase, eukaryoticsearch S-adenosyl-L-methionine-dependent methyltransferasesearch