1jqp Summary

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dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family

The structure was published by Olsen, J.G., Kadziola, A., Lauritzen, C., Pedersen, J., Larsen, S., and Dahl, S.W., in 2001 in a paper entitled "Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of dipeptidyl peptidase I. This molecule has the UniProt identifier P80067 (CATC_RAT)search. The sample contained 438 residues which is 100% of the natural sequence. Out of 438 residues 348 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A dipeptidyl peptidase I P80067 (25-462) (CATC_RAT)search Rattus norvegicussearch 100% 438 79%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80067 (25 - 462) dipeptidyl peptidase I Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P80067) Dipeptidyl peptidase I (cathepsin C), exclusion domainsearch, Papain-likesearch Lipocalinsearch, Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch, PF08773: Cathepsin C exclusion domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P80067) endoplasmic reticulumsearch lysosomesearch extracellular vesicular exosomesearch extracellular spacesearch Golgi apparatussearch response to organic substancesearch positive regulation of proteolysis involved in cellular protein catabolic processsearch positive regulation of apoptotic signaling pathwaysearch agingsearch apoptotic processsearch proteolysissearch T cell mediated cytotoxicitysearch identical protein bindingsearch peptidase activator activity involved in apoptotic processsearch cysteine-type peptidase activitysearch protein self-associationsearch chloride ion bindingsearch hydrolase activitysearch peptidase activitysearch phosphatase bindingsearch serine-type endopeptidase activitysearch chaperone bindingsearch cysteine-type endopeptidase activitysearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cathepsin C exclusionsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch