› 1jpy

X-ray diffraction
2.85Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Interleukin-17F Chains: A, B, X, Y
Molecule details ›
Chains: A, B, X, Y
Length: 137 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q96PD4 (Residues: 31-163; Coverage: 100%)
Gene name: IL17F
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P65
Unit cell:
a: 126.438Å b: 126.438Å c: 89.914Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.238 0.284
Expression system: unidentified baculovirus

Quick links

Citations

126 review citations

IL-17 and Th17 Cells.
Korn et al. (2009)
125 more

10 mentions without citation

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
Hymowitz et al. (2001)
9 more