1jpy Summary


Crystal structure of IL-17F

The structure was published by Hymowitz, S.G., Filvaroff, E.H., Yin, J.P., et al., Gurney, A.L., de Vos, A.M., and Starovasnik, M.A., in 2001 in a paper entitled "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of interleukin 17F.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A interleukin 17F Q96PD4 (31-163) (IL17F_HUMAN)search Homo sapienssearch 100% 137 88%
B interleukin 17F Q96PD4 (31-163) (IL17F_HUMAN)search Homo sapienssearch 100% 137 88%
X interleukin 17F Q96PD4 (31-163) (IL17F_HUMAN)search Homo sapienssearch 100% 137 88%
Y interleukin 17F Q96PD4 (31-163) (IL17F_HUMAN)search Homo sapienssearch 100% 137 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q96PD4 (31 - 163) interleukin 17F Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, X, Y (Q96PD4) Interleukin 17F, IL-17Fsearch Cystine-knot cytokinessearch PF06083: Interleukin-17search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, X, Y (Q96PD4) extracellular regionsearch extracellular spacesearch cartilage developmentsearch regulation of interleukin-8 biosynthetic processsearch negative regulation of angiogenesissearch regulation of interleukin-2 biosynthetic processsearch regulation of transforming growth factor beta receptor signaling pathwaysearch lymphotoxin A biosynthetic processsearch proteoglycan metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of interleukin-6 biosynthetic processsearch cytokine biosynthetic processsearch regulation of granulocyte macrophage colony-stimulating factor biosynthetic processsearch positive regulation of cytokine production involved in inflammatory responsesearch inflammatory responsesearch cytokine receptor bindingsearch protein homodimerization activitysearch cytokine activitysearch cytokine bindingsearch

Chain InterPro annotation
A, B, X, Y Interleukin-17 familysearch Interleukin-17, chordatasearch Cystine-knot cytokinesearch