1jpp Summary


The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin

The structure was published by Eklof Spink, K., Fridman, S.G., and Weis, W.I., in 2001 in a paper entitled "Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely BETA-CATENIN and ADENOMATOUS POLYPOSIS COLI PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-CATENIN Q02248 (134-671) (CTNB1_MOUSE)search Mus musculussearch < 90% 538 93%
B BETA-CATENIN Q02248 (134-671) (CTNB1_MOUSE)search Mus musculussearch < 90% 538 93%
C ADENOMATOUS POLYPOSIS COLI PROTEIN P25054 (1021-1035) (APC_HUMAN)search Homo sapienssearch < 90% 15 93%
D ADENOMATOUS POLYPOSIS COLI PROTEIN P25054 (1021-1035) (APC_HUMAN)search Homo sapienssearch < 90% 15 93%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q02248 (134 - 671) BETA-CATENIN Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
C, D APC 15 residue motifsearch
Chain InterPro annotation
A, B Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
C, D Adenomatous polyposis coli protein, 15 residue repeatsearch