1joc Summary

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EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate

The structure was published by Dumas, J.J., Merithew, E., Sudharshan, E., et al., Lawe, D., Corvera, S., and Lambright, D.G., in 2001 in a paper entitled "Multivalent endosome targeting by homodimeric EEA1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Early Endosomal Autoantigen 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Early Endosomal Autoantigen 1 Q15075 (1287-1324) (EEA1_HUMAN)search ,
Q15075 (1326-1411) (EEA1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
125 98%
B Early Endosomal Autoantigen 1 Q15075 (1287-1324) (EEA1_HUMAN)search ,
Q15075 (1326-1411) (EEA1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
125 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15075 (1287 - 1324) Early Endosomal Autoantigen 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Eea1 homodimerisation domainsearch, FYVE, a phosphatidylinositol-3-phosphate binding domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch, Zinc/RING finger domain, C3HC4 (zinc finger)search FYVE zinc fingersearch

Chain ID Molecular function (GO)
A, B (Q15075) metal ion bindingsearch

Chain InterPro annotation
A, B FYVE zinc fingersearch Zinc finger, FYVE/PHD-typesearch Zinc finger, RING/FYVE/PHD-typesearch Zinc finger, FYVE-relatedsearch