1jnk Summary



The structure was published by Xie, X., Gu, Y., Fox, T., et al., Caron, P.R., Wilson, K.P., and Su, M.S., in 1998 in a paper entitled "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of C-JUN N-TERMINAL KINASE. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 423 residues which is 91% of the natural sequence. Out of 423 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-JUN N-TERMINAL KINASE P53779 (1-423) (MK10_HUMAN)search Homo sapienssearch 91% 423 81%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (1 - 423) C-JUN N-TERMINAL KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P53779) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P53779) protein phosphorylationsearch activation of MAPK activitysearch innate immune responsesearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch JNK cascadesearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch JUN phosphorylationsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch signal transductionsearch toll-like receptor 9 signaling pathwaysearch phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch ATP bindingsearch protein bindingsearch JUN kinase activitysearch kinase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch nucleoplasmsearch mitochondrionsearch cytoplasmsearch cytosolsearch membranesearch nucleussearch plasma membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch