1jnk Summary



The structure was published by Xie, X., Gu, Y., Fox, T., et al., Caron, P.R., Wilson, K.P., and Su, M.S., in 1998 in a paper entitled "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of C-JUN N-TERMINAL KINASE. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 423 residues which is 91% of the natural sequence. Out of 423 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-JUN N-TERMINAL KINASE P53779 (1-423) (MK10_HUMAN)search Homo sapienssearch 91% 423 81%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (1 - 423) C-JUN N-TERMINAL KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P53779) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P53779) MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch nucleotide bindingsearch JUN kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch stress-activated MAPK cascadesearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch regulation of circadian rhythmsearch toll-like receptor signaling pathwaysearch JNK cascadesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch response to light stimulussearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch phosphorylationsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch JUN phosphorylationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch rhythmic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch activation of MAPK activitysearch innate immune responsesearch toll-like receptor 10 signaling pathwaysearch signal transductionsearch nucleoplasmsearch mitochondrionsearch nucleussearch plasma membranesearch membranesearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch