1jms Summary


Crystal Structure of the Catalytic Core of Murine Terminal Deoxynucleotidyl Transferase

The structure was published by Delarue, M., Boule, J.B., Lescar, J., et al., Sukumar, N., Rougeon, F., and Papanicolaou, C., in 2002 in a paper entitled "Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.36 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE. This molecule has the UniProt identifier P09838 (TDT_MOUSE)search. The sample contained 381 residues which is < 90% of the natural sequence. Out of 381 residues 358 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE P09838 (130-530) (TDT_MOUSE)search Mus musculussearch < 90% 381 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A DNA polymerase beta, N-terminal domain-likesearch, DNA polymerase beta-like, second domainsearch, DNA polymerase beta-likesearch DNA polymerase beta, N-terminal domain-likesearch, 5' to 3' exonuclease, C-terminal subdomainsearch, Beta Polymerase, domain 2search, Beta Polymerase, domain 3search Nucleotidyltransferase domainsearch, Fingers domain of DNA polymerase lambdasearch, Helix-hairpin-helix domainsearch, DNA polymerase beta thumbsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P09838) nucleussearch DNA polymerase activitysearch DNA-directed DNA polymerase activitysearch nucleotidyltransferase activitysearch DNA bindingsearch

Chain InterPro annotation
A DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase musearch DNA-directed DNA polymerase Xsearch DNA polymerase beta-like, N-terminal domainsearch DNA polymerase lambda, fingers domainsearch DNA polymerase family X, binding sitesearch DNA polymerase family Xsearch DNA polymerase family X lyase domainsearch DNA polymerase beta, palm domainsearch DNA polymerase beta, thumb domainsearch