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PDBe Entry: 1jle 
CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.8 Å, R-factor: 26.1%, Free R-factor: 33.7%, Spacegroup: P 21 21 21
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03/10/2001, deposition: 16/07/2001, last revision: 24/02/2009
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Ren, J.; Nichols, C.; Bird, L.; Chamberlain, P.; Weaver, K.; Short, S.; Stuart, D.I.; Stammers, D.K.
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Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.MOL.BIOL. vol:312, pag:795-805 (2001) [PubMed ID 11575933 ]
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HIV-1 REVERSE TRANSCRIPTASE, AIDS, NON-NUCLEOSIDE INHIBITOR, DRUG RESISTANCE MUTATIONS, DRUG DESIGN, TRANSFERASE
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2.7.7.49 ExPASy BRENDA 2.7.7.7 ExPASy BRENDA 3.1.26.4 ExPASy BRENDA 3.4.23.16 ExPASy BRENDA (A B)
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HIV-1 M:B_HXB2R 11706(A B)
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Gag-Pol polyprotein (Pr160Gag-Pol) [Contains: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (Retropepsin) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT); p51 RT; p15; Integrase (IN)] P04585 (A B)
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A, B
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1vrt, 1rth, 1vru, 1rti, 1rtj, 1rev, 1rt1, 1rt2, 1klm, 1rt3, 1rt4, 1rt5, 1rt6, 1rt7, 1c0t, 1c0u, 1c1b, 1c1c, 1dtq, 1dtt, 1ep4, 1fk9, 1fko, 1fkp, 1jkh, 1jlb, 1jlc, 1jlf, 1jla, 1jlq, 1jlg
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| A |
HIV-1 RT, A-CHAIN |
Protein |
P04585 (POL_HV1H2)
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560 |
93% |
| B |
HIV-1 RT, B-CHAIN |
Protein |
P04585 (POL_HV1H2)
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440 |
92% |
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