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PDBe Entry: 1jkx 
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 1.6 Å, R-factor: 22.1%, Free R-factor: 24.3%, Spacegroup: P 1
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30/11/2001, deposition: 13/07/2001, last revision: 24/02/2009
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Greasley, S.E.; Marsilje, T.H.; Cai, H.; Baker, S.; Benkovic, S.J.; Boger, D.L.; Wilson, I.A.
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Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
BIOCHEMISTRY vol:40, pag:13538-13547 (2001) [PubMed ID 11695901 ]
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PURINE BIOSYNTHESIS, ANTI-CANCER AGENT, ENZYME-ASSEMBLED MULTISUBSTRATE ADDUCT INHIBITOR COMPLEX, TRANSFERASE
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2.1.2.2 ExPASy BRENDA (A B C D)
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Escherichia coli 562(A B C D)
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Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) P08179 (A B C D)
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A, B, C, D
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| A, B, C, D |
PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE |
Protein |
P08179 (PUR3_ECOLI)
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212 |
98% |
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| A, B, C, D |
N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE |
138
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