1jen Summary

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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE

The structure was published by Ekstrom, J.L., Mathews, I.I., Stanley, B.A., Pegg, A.E., and Ealick, S.E., in 1999 in a paper entitled "The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (BETA CHAIN)) and PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (ALPHA CHAIN)).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (BETA CHAIN)) P17707 (1-67) (DCAM_HUMAN)search Homo sapienssearch 99% 67 85%
D PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (BETA CHAIN)) P17707 (1-67) (DCAM_HUMAN)search Homo sapienssearch 99% 67 85%
A PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (ALPHA CHAIN)) P17707 (69-334) (DCAM_HUMAN)search Homo sapienssearch 99% 267 93%
C PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (ALPHA CHAIN)) P17707 (69-334) (DCAM_HUMAN)search Homo sapienssearch 99% 267 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P17707 (1 - 67) PROTEIN (S-ADENOSYLMETHIONINE DECARBOXYLASE (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
B, D (P17707) S-adenosylmethionine decarboxylasesearch PF01536: Adenosylmethionine decarboxylasesearch
A, C (P17707) S-adenosylmethionine decarboxylasesearch S-adenosylmethionine decarboxylasesearch PF01536: Adenosylmethionine decarboxylasesearch

Chain ID Biological process (GO) Molecular function (GO)
B, D (P17707) spermidine biosynthetic processsearch spermine biosynthetic processsearch adenosylmethionine decarboxylase activitysearch
A, C (P17707) spermidine biosynthetic processsearch spermine biosynthetic processsearch adenosylmethionine decarboxylase activitysearch

Chain InterPro annotation
B, D S-adenosylmethionine decarboxylasesearch S-adenosylmethionine decarboxylase, coresearch
A, C S-adenosylmethionine decarboxylasesearch S-adenosylmethionine decarboxylase, coresearch S-adenosylmethionine decarboxylase subgroupsearch