1jeg Summary

pdbe.org/1jeg
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Solution structure of the SH3 domain from C-terminal Src Kinase complexed with a peptide from the tyrosine phosphatase PEP

The structure was published by Ghose, R., Shekhtman, A., Goger, M.J., Ji, H., and Cowburn, D., in 2001 in a paper entitled "A novel, specific interaction involving the Csk SH3 domain and its natural ligand." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely TYROSINE-PROTEIN KINASE CSK and HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE CSK P41241 (1-83) (CSK_MOUSE)search Mus musculussearch < 90% 83 72%
B HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP P29352 (605-629) (PTN22_MOUSE)search Mus musculussearch < 90% 25 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P41241 (1 - 83) TYROSINE-PROTEIN KINASE CSK Mus musculus
P29352 (605 - 629) HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch SH2 domainsearch, SH3 domainsearch
B
Chain InterPro annotation
A SH3 domainsearch
B