1jdw Summary

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CRYSTAL STRUCTURE AND MECHANISM OF L-ARGININE: GLYCINE AMIDINOTRANSFERASE: A MITOCHONDRIAL ENZYME INVOLVED IN CREATINE BIOSYNTHESIS

The structure was published by Humm, A., Fritsche, E., Steinbacher, S., and Huber, R., in 1997 in a paper entitled "Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of L-ARGININE\:GLYCINE AMIDINOTRANSFERASE. This molecule has the UniProt identifier P50440 (GATM_HUMAN)search. The sample contained 423 residues which is 100% of the natural sequence. Out of 423 residues 360 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A L-ARGININE\:GLYCINE AMIDINOTRANSFERASE P50440 (1-423) (GATM_HUMAN)search Homo sapienssearch 91% 423 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P50440 (1 - 423) L-ARGININE\:GLYCINE AMIDINOTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P50440) Amidinotransferasesearch L-arginine/glycine Amidinotransferase; Chain Asearch PF02274: Amidinotransferasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P50440) response to nutrientsearch cellular nitrogen compound metabolic processsearch embryo developmentsearch response to oxidative stresssearch creatine biosynthetic processsearch response to organic substancesearch small molecule metabolic processsearch response to peptide hormone stimulussearch tissue regenerationsearch creatine metabolic processsearch response to mercury ionsearch glycine amidinotransferase activitysearch transferase activitysearch amidinotransferase activitysearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch mitochondrial inner membranesearch mitochondrionsearch cytoplasmsearch mitochondrial intermembrane spacesearch membranesearch

Chain InterPro annotation
A Amidinotransferasesearch