1jdh Summary

pdbe.org/1jdh
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CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

The structure was published by Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W., in 2001 in a paper entitled "Tcf4 can specifically recognize beta-catenin using alternative conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely BETA-CATENIN and hTcf-4.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-CATENIN P35222 (135-663) (CTNB1_HUMAN)search Homo sapienssearch < 90% 529 96%
B hTcf-4 Q9NQB0 (12-49) (TF7L2_HUMAN)search Homo sapienssearch < 90% 38 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35222 (135 - 663) BETA-CATENIN Homo sapiens
Q9NQB0 (12 - 49) hTcf-4 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B beta-Catenine bound non-globular protein regionssearch N-terminal CTNNB1 bindingsearch

Chain ID Biological process (GO)
B (Q9NQB0) Wnt signaling pathwaysearch

Chain InterPro annotation
A Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B CTNNB1 binding, N-teminalsearch Transcription factor TCF/LEFsearch Catenin binding domainsearch