1jb6 Summary

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Crystal Structure of Dimerization Domain (1-33) of HNF-1alpha

The structure was published by Narayana, N., Hua, Q., and Weiss, M.A., in 2001 in a paper entitled "The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HEPATOCYTE NUCLEAR FACTOR 1-ALPHA.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEPATOCYTE NUCLEAR FACTOR 1-ALPHA P22361 (1-33) (HNF1A_MOUSE)search Mus musculussearch < 90% 33 100%
B HEPATOCYTE NUCLEAR FACTOR 1-ALPHA P22361 (1-33) (HNF1A_MOUSE)search Mus musculussearch < 90% 33 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22361 (1 - 33) HEPATOCYTE NUCLEAR FACTOR 1-ALPHA

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B Dimerization cofactor of HNF-1 alphasearch Hepatocyte nuclear factor 1 (HNF-1), N terminussearch
Chain InterPro annotation
A, B Hepatocyte nuclear factor 1, N-terminalsearch Hepatocyte nuclear factor 1, dimerisation domainsearch