1j8h Summary

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Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4

The structure was published by Hennecke, J. and Wiley, D.C., in 2002 in a paper entitled "Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This entry contains 13 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN P01903 (26-206) (DRA_HUMAN)search Homo sapienssearch < 90% 181 99%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-4 BETA CHAIN P13760 (30-221) (2B14_HUMAN)search Homo sapienssearch < 90% 192 93%
C HEMAGGLUTININ HA1 PEPTIDE CHAIN P03437 (322-334) (HEMA_I68A0)search Influenza A virus (A/Aichi/2/1968(H3N2))search 90% 13 100%
D T-CELL RECEPTOR ALPHA CHAIN P01848 (1-99) (TCA_HUMAN)search Homo sapienssearch < 90% 212 93%
E T-CELL RECEPTOR BETA CHAIN P01850 (1-134) (TRBC1_HUMAN)search Homo sapienssearch < 90% 246 97%


This entry contains 5 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 206) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN Homo sapiens
P13760 (30 - 221) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-4 BETA CHAIN Homo sapiens
P03437 (322 - 334) HEMAGGLUTININ HA1 PEPTIDE CHAIN Influenzavirus A
P01848 (1 - 99) T-CELL RECEPTOR ALPHA CHAIN Homo sapiens
P01850 (1 - 134) T-CELL RECEPTOR BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C (P03437) PF00509: Haemagglutininsearch
D V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch Domain of unknown function (DUF1968)search
E V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch Immunoglobulin C1-set domainsearch

Chain ID Cellular component (GO) Biological process (GO)
A (P01903) MHC class II protein complexsearch membranesearch immune responsesearch antigen processing and presentationsearch
B (P13760) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C
D Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
E Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch