1j7y Summary

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Crystal structure of partially ligated mutant of HbA

The structure was published by Miele, A.E., Draghi, F., Arcovito, A., et al., Brunori, M., Travaglini-Allocatelli, C., and Vallone, B., in 2001 in a paper entitled "Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Homo sapiens
P68871 (2 - 147) Hemoglobin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch membranesearch cytosolsearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen transportsearch receptor-mediated endocytosissearch bicarbonate transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch oxidation-reduction processsearch protein bindingsearch iron ion bindingsearch haptoglobin bindingsearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch small molecule metabolic processsearch renal absorptionsearch blood coagulationsearch nitric oxide transportsearch regulation of blood pressuresearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch heme bindingsearch hemoglobin bindingsearch iron ion bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch