1j7w Summary

pdbe.org/1j7w
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Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA

The structure was published by Miele, A.E., Draghi, F., Arcovito, A., et al., Brunori, M., Travaglini-Allocatelli, C., and Vallone, B., in 2001 in a paper entitled "Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely hemoglobin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) hemoglobin Homo sapiens
P68871 (2 - 147) hemoglobin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch oxygen bindingsearch protein bindingsearch heme bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) oxygen transportsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch blood coagulationsearch oxidation-reduction processsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch regulation of blood pressuresearch renal absorptionsearch protein heterooligomerizationsearch small molecule metabolic processsearch platelet aggregationsearch metal ion bindingsearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch heme bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch iron ion bindingsearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch