1j7w Summary

pdbe.org/1j7w
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Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA

The structure was published by Miele, A.E., Draghi, F., Arcovito, A., et al., Brunori, M., Travaglini-Allocatelli, C., and Vallone, B., in 2001 in a paper entitled "Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely hemoglobin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) hemoglobin Homo sapiens
P68871 (2 - 147) hemoglobin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch oxygen transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch receptor-mediated endocytosissearch extracellular regionsearch hemoglobin complexsearch cytosolsearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch
B, D (P68871) iron ion bindingsearch protein bindingsearch heme bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch transportsearch blood coagulationsearch platelet aggregationsearch renal absorptionsearch protein heterooligomerizationsearch oxidation-reduction processsearch small molecule metabolic processsearch regulation of blood pressuresearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular exosomesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch