1j7w Summary

pdbe.org/1j7w
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Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA

The structure was published by Miele, A.E., Draghi, F., Arcovito, A., et al., Brunori, M., Travaglini-Allocatelli, C., and Vallone, B., in 2001 in a paper entitled "Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely hemoglobin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) hemoglobin Homo sapiens
P68871 (2 - 147) hemoglobin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch peroxidase activitysearch oxygen transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch bicarbonate transportsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch
B, D (P68871) protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch hemoglobin bindingsearch oxygen bindingsearch heme bindingsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch blood coagulationsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch regulation of blood vessel sizesearch oxidation-reduction processsearch oxygen transportsearch small molecule metabolic processsearch platelet aggregationsearch renal absorptionsearch protein heterooligomerizationsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch