1j7s Summary

pdbe.org/1j7s
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Crystal Structure of deoxy HbalphaYQ, a mutant of HbA

The structure was published by Miele, A.E., Draghi, F., Arcovito, A., et al., Brunori, M., Travaglini-Allocatelli, C., and Vallone, B., in 2001 in a paper entitled "Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Homo sapiens
P68871 (2 - 147) Hemoglobin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch bicarbonate transportsearch transportsearch receptor-mediated endocytosissearch oxygen transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch
B, D (P68871) extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch oxygen transportsearch transportsearch bicarbonate transportsearch platelet aggregationsearch regulation of blood pressuresearch renal absorptionsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch nitric oxide transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch receptor-mediated endocytosissearch regulation of blood vessel sizesearch positive regulation of cell deathsearch small molecule metabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch