1j7l Summary


Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Complex

The structure was published by Burk, D.L., Hon, W.C., Leung, A.K., and Berghuis, A.M., in 2001 in a paper entitled "Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE P0A3Y5 (1-264) (KKA3_ENTFL)search Enterococcus faecalissearch 100% 264 99%
B AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE P0A3Y5 (1-264) (KKA3_ENTFL)search Enterococcus faecalissearch 100% 264 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A3Y5 (1 - 264) AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE Enterococcus faecalis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P0A3Y5) APH phosphotransferasessearch Phosphorylase Kinase; domain 1search, Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2search PF01636: Phosphotransferase enzyme familysearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P0A3Y5) transferase activity, transferring phosphorus-containing groupssearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch transferase activitysearch nucleotide bindingsearch kanamycin kinase activitysearch kinase activitysearch response to antibioticsearch phosphorylationsearch

Chain InterPro annotation
A, B Aminoglycoside phosphotransferasesearch Protein kinase-like domainsearch Aminoglycoside 3-phosphotransferasesearch