1j79 Summary

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Molecular Structure of Dihydroorotase: A Paradigm for Catalysis Through the Use of a Binuclear Metal Center

The structure was published by Thoden, J.B., Phillips Jr., G.N., Neal, T.M., Raushel, F.M., and Holden, H.M., in 2001 in a paper entitled "Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of dihydroorotase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A dihydroorotase P05020 (2-348) (PYRC_ECOLI)search Escherichia coli K-12search 97% 347 98%
B dihydroorotase P05020 (2-348) (PYRC_ECOLI)search Escherichia coli K-12search 97% 347 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05020 (2 - 348) dihydroorotase Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05020) Dihydroorotasesearch Metal-dependent hydrolasessearch PF01979: Amidohydrolase familysearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P05020) dihydroorotase activitysearch zinc ion bindingsearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidessearch metal ion bindingsearch hydrolase activitysearch pyrimidine nucleotide biosynthetic processsearch pyrimidine nucleobase biosynthetic processsearch 'de novo' UMP biosynthetic processsearch 'de novo' pyrimidine nucleobase biosynthetic processsearch

Chain InterPro annotation
A, B Dihydroorotase, conserved sitesearch Dihydroorotase homodimeric typesearch Amidohydrolase 1search