1j53 Summary

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Structure of the N-terminal Exonuclease Domain of the Epsilon Subunit of E.coli DNA Polymerase III at pH 8.5

The structure was published by Hamdan, S., Carr, P.D., Brown, S.E., Ollis, D.L., and Dixon, N.E., in 2002 in a paper entitled "Structural Basis for Proofreading during Replication of the Escherichia coli Chromosome" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of DNA polymerase III, epsilon chain. This molecule has the UniProt identifier P03007 (DPO3E_ECOLI)search. The sample contained 186 residues which is < 90% of the natural sequence. Out of 186 residues 172 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DNA polymerase III, epsilon chain P03007 (1-186) (DPO3E_ECOLI)search Escherichia coli K-12search < 90% 186 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03007 (1 - 186) DNA polymerase III, epsilon chain Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A DnaQ-like 3'-5' exonucleasesearch Nucleotidyltransferase; domain 5search Exonucleasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P03007) DNA-directed DNA polymerase activitysearch nucleic acid bindingsearch DNA bindingsearch exonuclease activitysearch DNA replicationsearch

Chain InterPro annotation
A DNA polymerase III, epsilon subunitsearch Exonucleasesearch DNA polymerase 3, epsilon subunitsearch Ribonuclease H-like domainsearch Exonuclease, RNase T/DNA polymerase IIIsearch