1j4x Summary

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PDB entry 1j4x (supersedes 1f5d)

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE C124S MUTANT-PEPTIDE COMPLEX

The structure was published by Schumacher, M.A., Todd, J.L., Rice, A.E., Tanner, K.G., and Denu, J.M., in 2002 in a paper entitled "Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 and DDE(AHP)(TPO)G(PTR)VATR.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 P51452 (2-185) (DUS3_HUMAN)search Homo sapienssearch 99% 184 96%
D DDE(AHP)(TPO)G(PTR)VATR Not available
Not available Not available 11 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P51452 (2 - 185) DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P51452) Dual specificity phosphatase-likesearch Protein tyrosine phosphatase superfamilysearch PF00782: Dual specificity phosphatase, catalytic domainsearch
D

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P51452) protein dephosphorylationsearch negative regulation of T cell activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch stress-activated MAPK cascadesearch negative regulation of T cell receptor signaling pathwaysearch negative regulation of MAPK cascadesearch toll-like receptor 3 signaling pathwaysearch negative regulation of JNK cascadesearch dephosphorylationsearch toll-like receptor 4 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch innate immune responsesearch peptidyl-tyrosine dephosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of mitotic cell cyclesearch toll-like receptor 5 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch in utero embryonic developmentsearch TRIF-dependent toll-like receptor signaling pathwaysearch negative regulation of ERK1 and ERK2 cascadesearch inactivation of MAPK activitysearch toll-like receptor 9 signaling pathwaysearch protein tyrosine/serine/threonine phosphatase activitysearch phosphoprotein phosphatase activitysearch hydrolase activitysearch phosphatase activitysearch protein tyrosine phosphatase activitysearch MAP kinase phosphatase activitysearch immunological synapsesearch nucleoplasmsearch nucleussearch cytosolsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Dual specificity phosphatase, catalytic domainsearch Protein-tyrosine/Dual specificity phosphatasesearch Atypical dual specificity phosphatase, subfamily Asearch Atypical dual specificity phosphatasesearch Dual specificity phosphatase, subgroup, catalytic domainsearch Dual specificity phosphatasesearch Protein-tyrosine phosphatase-likesearch
D