1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P47865) transporter activitysearch nitric oxide transmembrane transporter activitysearch water transmembrane transporter activitysearch ephrin receptor bindingsearch transmembrane transporter activitysearch potassium channel activitysearch ammonium transmembrane transporter activitysearch glycerol transmembrane transporter activitysearch intracellular cGMP activated cation channel activitysearch carbon dioxide transmembrane transporter activitysearch water channel activitysearch potassium ion transmembrane transporter activitysearch glycerol channel activitysearch membranesearch integral component of plasma membranesearch extracellular vesicular exosomesearch apical part of cellsearch brush bordersearch symbiont-containing vacuolesearch basolateral plasma membranesearch brush border membranesearch plasma membranesearch apical plasma membranesearch integral component of membranesearch symbiont-containing vacuole membranesearch cytoplasmsearch nuclear membranesearch axonsearch nucleussearch sarcolemmasearch basal plasma membranesearch dense core granule membranesearch cellular response to cAMPsearch cellular response to dexamethasone stimulussearch wound healingsearch pancreatic juice secretionsearch ammonium transportsearch cellular response to inorganic substancesearch lipid digestionsearch secretion by cellsearch multicellular organismal water homeostasissearch cellular response to UVsearch positive regulation of angiogenesissearch potassium ion transmembrane transportsearch cGMP biosynthetic processsearch metanephric proximal straight tubule developmentsearch cellular response to hydrogen peroxidesearch ammonium transmembrane transportsearch lateral ventricle developmentsearch corticotropin secretionsearch cellular response to hypoxiasearch positive regulation of saliva secretionsearch cell volume homeostasissearch carbon dioxide transmembrane transportsearch cellular response to mercury ionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch negative regulation of apoptotic processsearch water transportsearch cellular response to nitric oxidesearch camera-type eye morphogenesissearch positive regulation of fibroblast proliferationsearch cellular water homeostasissearch glycerol transportsearch cation transmembrane transportsearch cellular homeostasissearch cellular response to stresssearch cerebrospinal fluid secretionsearch response to drugsearch carbon dioxide transportsearch metanephric glomerulus vasculature developmentsearch transepithelial water transportsearch cellular hyperosmotic responsesearch cellular response to copper ionsearch metanephric proximal convoluted tubule segment 2 developmentsearch maintenance of symbiont-containing vacuole by hostsearch nitric oxide transportsearch transportsearch cellular response to mechanical stimulussearch cellular response to retinoic acidsearch cellular response to salt stresssearch renal water absorptionsearch renal water transportsearch positive regulation of cell migrationsearch establishment or maintenance of actin cytoskeleton polaritysearch metanephric descending thin limb developmentsearch potassium ion transportsearch odontogenesissearch sensory perception of painsearch secretory granule organizationsearch glomerular filtrationsearch water homeostasissearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search