1j4n Summary


Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P47865) carbon dioxide transmembrane transportsearch cellular response to dexamethasone stimulussearch secretion by cellsearch cellular response to mercury ionsearch wound healingsearch ammonium transmembrane transportsearch water transportsearch lateral ventricle developmentsearch potassium ion transmembrane transportsearch carbon dioxide transportsearch pancreatic juice secretionsearch water homeostasissearch cellular response to UVsearch positive regulation of angiogenesissearch cellular response to inorganic substancesearch cellular response to mechanical stimulussearch positive regulation of cell migrationsearch sensory perception of painsearch glycerol transportsearch establishment or maintenance of actin cytoskeleton polaritysearch cellular response to hypoxiasearch ammonium transportsearch response to drugsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch secretory granule organizationsearch negative regulation of apoptotic processsearch metanephric descending thin limb developmentsearch cellular response to stresssearch maintenance of symbiont-containing vacuole by hostsearch camera-type eye morphogenesissearch cellular response to salt stresssearch multicellular organismal water homeostasissearch odontogenesissearch cellular hyperosmotic responsesearch cGMP biosynthetic processsearch cell volume homeostasissearch transepithelial water transportsearch metanephric glomerulus vasculature developmentsearch cellular response to hydrogen peroxidesearch cellular response to copper ionsearch cellular response to retinoic acidsearch nitric oxide transportsearch lipid digestionsearch cerebrospinal fluid secretionsearch glomerular filtrationsearch cellular homeostasissearch positive regulation of saliva secretionsearch cellular response to nitric oxidesearch renal water transportsearch metanephric proximal convoluted tubule segment 2 developmentsearch corticotropin secretionsearch renal water absorptionsearch metanephric proximal straight tubule developmentsearch positive regulation of fibroblast proliferationsearch transportsearch cellular response to cAMPsearch potassium ion transportsearch nucleussearch brush bordersearch symbiont-containing vacuole membranesearch basolateral plasma membranesearch integral component of membranesearch nuclear membranesearch membranesearch apical part of cellsearch plasma membranesearch apical plasma membranesearch basal plasma membranesearch axonsearch symbiont-containing vacuolesearch extracellular vesicular exosomesearch sarcolemmasearch brush border membranesearch dense core granule membranesearch cytoplasmsearch glycerol transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch transmembrane transporter activitysearch water transmembrane transporter activitysearch intracellular cGMP activated cation channel activitysearch water channel activitysearch potassium channel activitysearch nitric oxide transmembrane transporter activitysearch ephrin receptor bindingsearch potassium ion transmembrane transporter activitysearch transporter activitysearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search