1j4n Summary


Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P47865) transportsearch water transportsearch cellular response to mercury ionsearch carbon dioxide transmembrane transportsearch cellular response to dexamethasone stimulussearch metanephric descending thin limb developmentsearch metanephric proximal convoluted tubule segment 2 developmentsearch lateral ventricle developmentsearch cellular response to UVsearch positive regulation of angiogenesissearch cellular response to inorganic substancesearch cellular hyperosmotic responsesearch cGMP biosynthetic processsearch cellular response to stresssearch secretory granule organizationsearch metanephric proximal straight tubule developmentsearch glycerol transportsearch wound healingsearch potassium ion transportsearch maintenance of symbiont-containing vacuole by hostsearch secretion by cellsearch nitric oxide transportsearch establishment or maintenance of actin cytoskeleton polaritysearch ammonium transportsearch cell volume homeostasissearch transepithelial water transportsearch renal water transportsearch potassium ion transmembrane transportsearch corticotropin secretionsearch cellular response to retinoic acidsearch cellular response to salt stresssearch cellular response to hydrogen peroxidesearch cellular response to copper ionsearch metanephric glomerulus vasculature developmentsearch ammonium transmembrane transportsearch camera-type eye morphogenesissearch response to drugsearch glomerular filtrationsearch renal water absorptionsearch carbon dioxide transportsearch positive regulation of saliva secretionsearch cellular response to cAMPsearch sensory perception of painsearch lipid digestionsearch cellular homeostasissearch water homeostasissearch cellular response to hypoxiasearch positive regulation of cell migrationsearch negative regulation of apoptotic processsearch positive regulation of fibroblast proliferationsearch cellular response to mechanical stimulussearch membranesearch brush bordersearch symbiont-containing vacuolesearch plasma membranesearch apical part of cellsearch apical plasma membranesearch nucleussearch basolateral plasma membranesearch integral component of membranesearch nuclear membranesearch extracellular vesicular exosomesearch basal plasma membranesearch axonsearch dense core granule membranesearch sarcolemmasearch brush border membranesearch transporter activitysearch glycerol transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch transmembrane transporter activitysearch intracellular cGMP activated cation channel activitysearch carbon dioxide transmembrane transporter activitysearch potassium ion transmembrane transporter activitysearch ephrin receptor bindingsearch water transmembrane transporter activitysearch potassium channel activitysearch water channel activitysearch nitric oxide transmembrane transporter activitysearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search