1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P47865) positive regulation of angiogenesissearch cellular hyperosmotic responsesearch secretory granule organizationsearch cellular response to UVsearch cellular response to mercury ionsearch ammonium transportsearch response to drugsearch transportsearch renal water absorptionsearch positive regulation of saliva secretionsearch cellular response to mechanical stimulussearch metanephric descending thin limb developmentsearch metanephric glomerulus vasculature developmentsearch maintenance of symbiont-containing vacuole by hostsearch cGMP biosynthetic processsearch cellular response to stresssearch cell volume homeostasissearch nitric oxide transportsearch glycerol transportsearch renal water transportsearch camera-type eye morphogenesissearch cellular response to salt stresssearch sensory perception of painsearch potassium ion transmembrane transportsearch cellular response to inorganic substancesearch secretion by cellsearch carbon dioxide transportsearch transepithelial water transportsearch metanephric proximal convoluted tubule segment 2 developmentsearch positive regulation of cell migrationsearch lateral ventricle developmentsearch positive regulation of fibroblast proliferationsearch cellular homeostasissearch cellular response to hydrogen peroxidesearch potassium ion transportsearch cellular response to copper ionsearch glomerular filtrationsearch negative regulation of apoptotic processsearch carbon dioxide transmembrane transportsearch cellular response to dexamethasone stimulussearch lipid digestionsearch wound healingsearch water transportsearch water homeostasissearch cellular response to retinoic acidsearch cellular response to hypoxiasearch corticotropin secretionsearch establishment or maintenance of actin cytoskeleton polaritysearch metanephric proximal straight tubule developmentsearch cellular response to cAMPsearch apical plasma membranesearch membranesearch extracellular vesicular exosomesearch symbiont-containing vacuolesearch basolateral plasma membranesearch dense core granule membranesearch brush bordersearch basal plasma membranesearch plasma membranesearch sarcolemmasearch nuclear membranesearch nucleussearch integral to membranesearch apical part of cellsearch brush border membranesearch transporter activitysearch intracellular cGMP activated cation channel activitysearch ammonia transmembrane transporter activitysearch transmembrane transporter activitysearch nitric oxide transmembrane transporter activitysearch glycerol transmembrane transporter activitysearch water transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch potassium ion transmembrane transporter activitysearch water channel activitysearch ephrin receptor bindingsearch potassium channel activitysearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search