1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47865) metanephric descending thin limb developmentsearch transportsearch cellular response to hydrogen peroxidesearch cellular response to dexamethasone stimulussearch cellular response to salt stresssearch cellular response to copper ionsearch cellular response to retinoic acidsearch cell volume homeostasissearch renal water transportsearch glomerular filtrationsearch water homeostasissearch potassium ion transmembrane transportsearch carbon dioxide transportsearch water transportsearch transepithelial water transportsearch ammonium transportsearch cellular response to inorganic substancesearch cerebrospinal fluid secretionsearch positive regulation of cell migrationsearch nitric oxide transportsearch establishment or maintenance of actin cytoskeleton polaritysearch response to drugsearch cellular response to stresssearch cellular response to mechanical stimulussearch metanephric proximal convoluted tubule segment 2 developmentsearch negative regulation of apoptotic processsearch positive regulation of fibroblast proliferationsearch camera-type eye morphogenesissearch cellular response to nitric oxidesearch positive regulation of saliva secretionsearch cellular response to cAMPsearch maintenance of symbiont-containing vacuole by hostsearch metanephric proximal straight tubule developmentsearch ammonium transmembrane transportsearch cellular response to hypoxiasearch cellular homeostasissearch potassium ion transportsearch renal water absorptionsearch carbon dioxide transmembrane transportsearch glycerol transportsearch cellular response to UVsearch positive regulation of angiogenesissearch secretion by cellsearch cellular response to mercury ionsearch sensory perception of painsearch metanephric glomerulus vasculature developmentsearch lipid digestionsearch wound healingsearch cellular hyperosmotic responsesearch odontogenesissearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch pancreatic juice secretionsearch multicellular organismal water homeostasissearch cGMP biosynthetic processsearch lateral ventricle developmentsearch secretory granule organizationsearch corticotropin secretionsearch potassium channel activitysearch water transmembrane transporter activitysearch ephrin receptor bindingsearch intracellular cGMP activated cation channel activitysearch glycerol transmembrane transporter activitysearch transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch water channel activitysearch nitric oxide transmembrane transporter activitysearch transporter activitysearch ammonium transmembrane transporter activitysearch potassium ion transmembrane transporter activitysearch apical part of cellsearch symbiont-containing vacuole membranesearch cytoplasmsearch apical plasma membranesearch nucleussearch basal plasma membranesearch basolateral plasma membranesearch nuclear membranesearch brush bordersearch plasma membranesearch sarcolemmasearch extracellular vesicular exosomesearch brush border membranesearch integral component of membranesearch symbiont-containing vacuolesearch dense core granule membranesearch membranesearch axonsearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search