1j4n Summary


Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47865) glomerular filtrationsearch renal water transportsearch cGMP biosynthetic processsearch transportsearch potassium ion transportsearch water transportsearch cell volume homeostasissearch cellular water homeostasissearch carbon dioxide transportsearch ammonium transportsearch glycerol transportsearch sensory perception of painsearch cellular homeostasissearch lateral ventricle developmentsearch water homeostasissearch pancreatic juice secretionsearch nitric oxide transportsearch positive regulation of cell migrationsearch establishment or maintenance of actin cytoskeleton polaritysearch secretion by cellsearch cerebrospinal fluid secretionsearch secretory granule organizationsearch cellular response to stresssearch cellular response to UVsearch transepithelial water transportsearch carbon dioxide transmembrane transportsearch wound healingsearch odontogenesissearch response to drugsearch negative regulation of apoptotic processsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch lipid digestionsearch positive regulation of angiogenesissearch positive regulation of saliva secretionsearch positive regulation of fibroblast proliferationsearch camera-type eye morphogenesissearch multicellular organismal water homeostasissearch corticotropin secretionsearch renal water absorptionsearch cellular response to hydrogen peroxidesearch cellular response to inorganic substancesearch cellular response to mechanical stimulussearch cellular response to copper ionsearch cellular response to mercury ionsearch cellular response to retinoic acidsearch cellular response to cAMPsearch cellular response to hypoxiasearch cellular response to salt stresssearch cellular hyperosmotic responsesearch cellular response to dexamethasone stimulussearch cellular response to nitric oxidesearch potassium ion transmembrane transportsearch metanephric descending thin limb developmentsearch metanephric proximal straight tubule developmentsearch metanephric proximal convoluted tubule segment 2 developmentsearch metanephric glomerulus vasculature developmentsearch ammonium transmembrane transportsearch maintenance of symbiont-containing vacuole by hostsearch cation transmembrane transportsearch transporter activitysearch intracellular cGMP activated cation channel activitysearch potassium channel activitysearch water transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch potassium ion transmembrane transporter activitysearch glycerol transmembrane transporter activitysearch water channel activitysearch glycerol channel activitysearch transmembrane transporter activitysearch nitric oxide transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch ephrin receptor bindingsearch nucleussearch cytoplasmsearch plasma membranesearch integral component of plasma membranesearch brush bordersearch basal plasma membranesearch membranesearch integral component of membranesearch basolateral plasma membranesearch apical plasma membranesearch symbiont-containing vacuolesearch symbiont-containing vacuole membranesearch axonsearch brush border membranesearch nuclear membranesearch dense core granule membranesearch sarcolemmasearch apical part of cellsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search