1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P47865) membranesearch brush bordersearch integral component of plasma membranesearch apical part of cellsearch axonsearch basolateral plasma membranesearch symbiont-containing vacuolesearch nucleussearch plasma membranesearch apical plasma membranesearch integral component of membranesearch nuclear membranesearch brush border membranesearch sarcolemmasearch basal plasma membranesearch extracellular exosomesearch dense core granule membranesearch cytoplasmsearch symbiont-containing vacuole membranesearch transporter activitysearch glycerol transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch transmembrane transporter activitysearch water transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch potassium channel activitysearch water channel activitysearch intracellular cGMP activated cation channel activitysearch ephrin receptor bindingsearch nitric oxide transmembrane transporter activitysearch glycerol channel activitysearch potassium ion transmembrane transporter activitysearch transportsearch potassium ion transmembrane transportsearch carbon dioxide transmembrane transportsearch cellular response to UVsearch cellular response to mercury ionsearch ammonium transmembrane transportsearch water transportsearch cellular response to retinoic acidsearch cellular response to dexamethasone stimulussearch metanephric proximal convoluted tubule segment 2 developmentsearch cellular response to stresssearch secretory granule organizationsearch sensory perception of painsearch potassium ion transportsearch corticotropin secretionsearch lateral ventricle developmentsearch lipid digestionsearch cellular response to copper ionsearch maintenance of symbiont-containing vacuole by hostsearch positive regulation of angiogenesissearch renal water absorptionsearch cGMP biosynthetic processsearch cellular response to mechanical stimulussearch secretion by cellsearch wound healingsearch cellular response to inorganic substancesearch cellular hyperosmotic responsesearch cerebrospinal fluid secretionsearch nitric oxide transportsearch carbon dioxide transportsearch cellular homeostasissearch glycerol transportsearch cellular water homeostasissearch positive regulation of cell migrationsearch glomerular filtrationsearch camera-type eye morphogenesissearch cellular response to nitric oxidesearch response to drugsearch renal water transportsearch transepithelial water transportsearch cellular response to salt stresssearch cellular response to hydrogen peroxidesearch establishment or maintenance of actin cytoskeleton polaritysearch positive regulation of saliva secretionsearch cation transmembrane transportsearch cell volume homeostasissearch ammonium transportsearch positive regulation of fibroblast proliferationsearch metanephric glomerulus vasculature developmentsearch cellular response to cAMPsearch metanephric descending thin limb developmentsearch pancreatic juice secretionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch negative regulation of apoptotic processsearch water homeostasissearch cellular response to hypoxiasearch metanephric proximal straight tubule developmentsearch odontogenesissearch multicellular organismal water homeostasissearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search