1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P47865) membranesearch brush bordersearch axonsearch basolateral plasma membranesearch symbiont-containing vacuole membranesearch nuclear membranesearch extracellular vesicular exosomesearch sarcolemmasearch apical part of cellsearch plasma membranesearch apical plasma membranesearch nucleussearch integral component of membranesearch cytoplasmsearch basal plasma membranesearch brush border membranesearch symbiont-containing vacuolesearch dense core granule membranesearch cell volume homeostasissearch camera-type eye morphogenesissearch carbon dioxide transmembrane transportsearch establishment or maintenance of actin cytoskeleton polaritysearch metanephric proximal straight tubule developmentsearch cerebrospinal fluid secretionsearch cellular response to mercury ionsearch cellular response to UVsearch positive regulation of angiogenesissearch lipid digestionsearch secretion by cellsearch cellular response to cAMPsearch cellular response to copper ionsearch cellular response to dexamethasone stimulussearch metanephric descending thin limb developmentsearch water transportsearch glycerol transportsearch cellular response to salt stresssearch potassium ion transportsearch maintenance of symbiont-containing vacuole by hostsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch transportsearch negative regulation of apoptotic processsearch cellular response to mechanical stimulussearch cellular response to retinoic acidsearch cellular response to inorganic substancesearch cellular hyperosmotic responsesearch cGMP biosynthetic processsearch lateral ventricle developmentsearch pancreatic juice secretionsearch multicellular organismal water homeostasissearch nitric oxide transportsearch glomerular filtrationsearch cellular response to stresssearch response to drugsearch potassium ion transmembrane transportsearch secretory granule organizationsearch carbon dioxide transportsearch transepithelial water transportsearch ammonium transportsearch cellular response to hydrogen peroxidesearch positive regulation of fibroblast proliferationsearch metanephric proximal convoluted tubule segment 2 developmentsearch corticotropin secretionsearch cellular response to nitric oxidesearch odontogenesissearch wound healingsearch water homeostasissearch cellular homeostasissearch sensory perception of painsearch renal water absorptionsearch metanephric glomerulus vasculature developmentsearch renal water transportsearch cellular response to hypoxiasearch positive regulation of saliva secretionsearch ammonium transmembrane transportsearch positive regulation of cell migrationsearch glycerol transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch transmembrane transporter activitysearch water transmembrane transporter activitysearch intracellular cGMP activated cation channel activitysearch potassium ion transmembrane transporter activitysearch water channel activitysearch nitric oxide transmembrane transporter activitysearch ephrin receptor bindingsearch carbon dioxide transmembrane transporter activitysearch potassium channel activitysearch transporter activitysearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search