1j4n Summary

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Crystal Structure of the AQP1 water channel

The structure was published by Sui, H., Han, B.G., Lee, J.K., Walian, P., and Jap, B.K., in 2001 in a paper entitled "Structural basis of water-specific transport through the AQP1 water channel." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AQUAPORIN 1. This molecule has the UniProt identifier P47865 (AQP1_BOVIN)search. The sample contained 271 residues which is 100% of the natural sequence. Out of 271 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AQUAPORIN 1 P47865 (1-271) (AQP1_BOVIN)search Bos taurussearch 100% 271 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47865 (1 - 271) AQUAPORIN 1 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47865) Aquaporin-likesearch Glycerol uptake facilitator protein.search PF00230: Major intrinsic proteinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P47865) transporter activitysearch glycerol transmembrane transporter activitysearch carbon dioxide transmembrane transporter activitysearch transmembrane transporter activitysearch ammonium transmembrane transporter activitysearch potassium channel activitysearch intracellular cGMP activated cation channel activitysearch water transmembrane transporter activitysearch ephrin receptor bindingsearch water channel activitysearch glycerol channel activitysearch nitric oxide transmembrane transporter activitysearch potassium ion transmembrane transporter activitysearch maintenance of symbiont-containing vacuole by hostsearch potassium ion transmembrane transportsearch metanephric glomerulus vasculature developmentsearch glycerol transportsearch cellular water homeostasissearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch cellular response to inorganic substancesearch response to drugsearch cellular response to hydrogen peroxidesearch cell volume homeostasissearch cellular response to mercury ionsearch cerebrospinal fluid secretionsearch water transportsearch cellular response to dexamethasone stimulussearch wound healingsearch secretion by cellsearch transportsearch cellular response to UVsearch positive regulation of angiogenesissearch metanephric proximal straight tubule developmentsearch lateral ventricle developmentsearch cellular response to salt stresssearch secretory granule organizationsearch camera-type eye morphogenesissearch cellular hyperosmotic responsesearch positive regulation of saliva secretionsearch ammonium transportsearch cGMP biosynthetic processsearch cellular response to stresssearch cellular response to mechanical stimulussearch nitric oxide transportsearch multicellular organismal water homeostasissearch metanephric proximal convoluted tubule segment 2 developmentsearch potassium ion transportsearch carbon dioxide transmembrane transportsearch cellular response to copper ionsearch cellular response to retinoic acidsearch glomerular filtrationsearch cellular response to hypoxiasearch establishment or maintenance of actin cytoskeleton polaritysearch renal water transportsearch positive regulation of fibroblast proliferationsearch ammonium transmembrane transportsearch transepithelial water transportsearch cellular response to cAMPsearch cellular response to nitric oxidesearch cellular homeostasissearch sensory perception of painsearch lipid digestionsearch negative regulation of apoptotic processsearch water homeostasissearch renal water absorptionsearch carbon dioxide transportsearch metanephric descending thin limb developmentsearch odontogenesissearch corticotropin secretionsearch positive regulation of cell migrationsearch pancreatic juice secretionsearch basolateral plasma membranesearch apical plasma membranesearch apical part of cellsearch symbiont-containing vacuole membranesearch plasma membranesearch sarcolemmasearch axonsearch brush bordersearch extracellular vesicular exosomesearch symbiont-containing vacuolesearch brush border membranesearch nucleussearch nuclear membranesearch integral component of membranesearch cytoplasmsearch basal plasma membranesearch membranesearch dense core granule membranesearch integral component of plasma membranesearch

Chain InterPro annotation
A Major intrinsic proteinsearch Major intrinsic protein, conserved sitesearch Aquaporin-likesearch Aquaporin 1search