1j41 Summary

pdbe.org/1j41
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Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed)

The structure was published by Adachi, S., Park, S.-Y., Tame, J.R.H., Shiro, Y., and Shibayama, N., in 2003 in a paper entitled "Direct observation of photolysis-induced tertiary structural changes in hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha Chain and Hemoglobin beta Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha Chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta Chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C, E, G (P69905) oxygen transportsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch heme bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch iron ion bindingsearch cytosolsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch endocytic vesicle lumensearch
B, D, F, H (P68871) bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch small molecule metabolic processsearch renal absorptionsearch blood coagulationsearch transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch platelet aggregationsearch nitric oxide transportsearch heme bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch