1j41 Summary

pdbe.org/1j41
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Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed)

The structure was published by Adachi, S., Park, S.-Y., Tame, J.R.H., Shiro, Y., and Shibayama, N., in 2003 in a paper entitled "Direct observation of photolysis-induced tertiary structural changes in hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha Chain and Hemoglobin beta Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha Chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta Chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C, E, G (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transportsearch oxidation-reduction processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch transportsearch receptor-mediated endocytosissearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular regionsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch membranesearch endocytic vesicle lumensearch
B, D, F, H (P68871) oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch protein bindingsearch heme bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch small molecule metabolic processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch regulation of blood pressuresearch renal absorptionsearch transportsearch positive regulation of cell deathsearch nitric oxide transportsearch platelet aggregationsearch hydrogen peroxide catabolic processsearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch