1j3z Summary

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Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed)

The structure was published by Adachi, S., Park, S.-Y., Tame, J.R.H., Shiro, Y., and Shibayama, N., in 2003 in a paper entitled "Direct observation of photolysis-induced tertiary structural changes in hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha Chain and Hemoglobin beta Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha Chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta Chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C, E, G (P69905) oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch hemoglobin complexsearch extracellular exosomesearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch cytosolsearch heme bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch
B, D, F, H (P68871) regulation of blood pressuresearch platelet aggregationsearch oxidation-reduction processsearch oxygen transportsearch positive regulation of cell deathsearch renal absorptionsearch bicarbonate transportsearch protein heterooligomerizationsearch nitric oxide transportsearch regulation of blood vessel sizesearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch