1j3y Summary

pdbe.org/1j3y
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Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed)

The structure was published by Adachi, S., Park, S.-Y., Tame, J.R.H., Shiro, Y., and Shibayama, N., in 2003 in a paper entitled "Direct observation of photolysis-induced tertiary structural changes in hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha Chain and Hemoglobin beta Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha Chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta Chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C, E, G (P69905) hemoglobin complexsearch blood microparticlesearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch transportsearch small molecule metabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch oxygen transportsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch protein bindingsearch metal ion bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch
B, D, F, H (P68871) blood microparticlesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch oxygen transportsearch renal absorptionsearch regulation of blood vessel sizesearch blood coagulationsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch protein heterooligomerizationsearch small molecule metabolic processsearch receptor-mediated endocytosissearch platelet aggregationsearch positive regulation of cell deathsearch oxidation-reduction processsearch transportsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch hemoglobin bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch