1j3y Summary

pdbe.org/1j3y
spacer

Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed)

The structure was published by Adachi, S., Park, S.-Y., Tame, J.R.H., Shiro, Y., and Shibayama, N., in 2003 in a paper entitled "Direct observation of photolysis-induced tertiary structural changes in hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha Chain and Hemoglobin beta Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha Chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta Chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha Chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta Chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C, E, G (P69905) haptoglobin-hemoglobin complexsearch extracellular regionsearch membranesearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxygen transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch
B, D, F, H (P68871) hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch small molecule metabolic processsearch oxygen transportsearch platelet aggregationsearch positive regulation of cell deathsearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch regulation of blood pressuresearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch