1j3h Summary


Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit

The structure was published by Akamine, P., Madhusudan, Wu, J., Xuong, N.-H., Ten Eyck, L.F., and Taylor, S.S., in 2003 in a paper entitled "Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of cAMP-dependent protein kinase, alpha-catalytic subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase, alpha-catalytic subunit P05132 (2-351) (KAPCA_MOUSE)search Mus musculussearch 96% 350 94%
B cAMP-dependent protein kinase, alpha-catalytic subunit P05132 (2-351) (KAPCA_MOUSE)search Mus musculussearch 96% 350 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05132 (2 - 351) cAMP-dependent protein kinase, alpha-catalytic subunit Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05132) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P05132) mitochondrionsearch cytoplasmsearch ciliumsearch nucleussearch membranesearch nucleoplasmsearch plasma membranesearch cytosolsearch sperm midpiecesearch motile ciliumsearch ciliary basesearch extracellular vesicular exosomesearch neuromuscular junctionsearch centrosomesearch cell projectionsearch AMP-activated protein kinase complexsearch protein autophosphorylationsearch regulation of proteasomal protein catabolic processsearch protein phosphorylationsearch peptidyl-serine phosphorylationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch regulation of tight junction assemblysearch neural tube closuresearch regulation of synaptic transmissionsearch regulation of osteoblast differentiationsearch sperm capacitationsearch positive regulation of protein export from nucleussearch cellular response to parathyroid hormone stimulussearch peptidyl-threonine phosphorylationsearch positive regulation of cell cycle arrestsearch mesoderm formationsearch regulation of protein processingsearch phosphorylationsearch cellular response to glucose stimulussearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch protein kinase bindingsearch protein bindingsearch protein serine/threonine/tyrosine kinase activitysearch cAMP-dependent protein kinase activitysearch transferase activitysearch nucleotide bindingsearch protein kinase A regulatory subunit bindingsearch ubiquitin protein ligase bindingsearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch