1j21 Summary

pdbe.org/1j21
spacer

Crystal Structure of Thermus thermophilus HB8 Argininosuccinate Synthetase in complex with ATP and citrulline

The structure was published by Goto, M., Omi, R., Miyahara, I., Sugahara, M., and Hirotsu, K., in 2003 in a paper entitled "Structures of argininosuccinate synthetase in enzyme-ATP-substrates and enzyme-AMP-product forms" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Argininosuccinate Synthetase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Argininosuccinate Synthetase P59846 (1-400) (ASSY_THET8)search Thermus thermophilus HB8search 100% 400 95%
B Argininosuccinate Synthetase P59846 (1-400) (ASSY_THET8)search Thermus thermophilus HB8search 100% 400 95%
C Argininosuccinate Synthetase P59846 (1-400) (ASSY_THET8)search Thermus thermophilus HB8search 100% 400 95%
D Argininosuccinate Synthetase P59846 (1-400) (ASSY_THET8)search Thermus thermophilus HB8search 100% 400 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P59846 (1 - 400) Argininosuccinate Synthetase Thermus thermophilus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P59846) N-type ATP pyrophosphatasessearch, Argininosuccinate synthetase, C-terminal domainsearch HUPssearch, Argininosuccinate synthetase, chain A, domain 2search PF00764: Arginosuccinate synthasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P59846) arginine biosynthetic processsearch cellular amino acid biosynthetic processsearch cytoplasmsearch argininosuccinate synthase activitysearch ATP bindingsearch ligase activitysearch nucleotide bindingsearch

Chain InterPro annotation
A, B, C, D Argininosuccinate synthasesearch Rossmann-like alpha/beta/alpha sandwich foldsearch Argininosuccinate synthase, conserved sitesearch Argininosuccinate synthase, type 1 subfamilysearch Argininosuccinate synthetase, catalytic/multimerisation domain bodysearch