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Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form

X-ray diffraction
2.61Å resolution
PDB entry 1j1d coloured by chain, front view.
PDB entry 1j1d coloured by chain, side view.
PDB entry 1j1d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cardiac Troponin complex
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Multimeric state: hetero trimer
Accessible surface area: 20599.27 Å2
Buried surface area: 9756.58 Å2
Dissociation area: 2,536.25 Å2
Dissociation energy (ΔGdiss): 30.12 kcal/mol
Dissociation entropy (TΔSdiss): 12.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148573
Complex Portal ID: CPX-3280
Assembly 2
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Assembly Name: Cardiac Troponin complex
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Multimeric state: hetero trimer
Accessible surface area: 21427.92 Å2
Buried surface area: 8843.01 Å2
Dissociation area: 2,416.07 Å2
Dissociation energy (ΔGdiss): 31.62 kcal/mol
Dissociation entropy (TΔSdiss): 12.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148573
Complex Portal ID: CPX-3280

Macromolecules

Troponin C, slow skeletal and cardiac muscles
Chains: A, D
Length: 161 amino acids
Theoretical weight: 18.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-161; Coverage: 100%)
Gene names: TNNC, TNNC1
Pfam:
InterPro:
CATH: EF-hand
SCOP: Calmodulin-like
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1d, assembly 1, front view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1d, assembly 1, side view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1d, assembly 1, top view.
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Troponin T, cardiac muscle
Chains: B, E
Length: 106 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45379 (Residues: 193-298; Coverage: 36%)
Gene name: TNNT2
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin T
Troponin T, cardiac muscle in PDB entry 1j1d, assembly 1, front view.
Troponin T, cardiac muscle in PDB entry 1j1d, assembly 1, side view.
Troponin T, cardiac muscle in PDB entry 1j1d, assembly 1, top view.
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Troponin I, cardiac muscle
Chains: C, F
Length: 133 amino acids
Theoretical weight: 15.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19429 (Residues: 31-163; Coverage: 63%)
Gene names: TNNC1, TNNI3
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin I
Troponin I, cardiac muscle in PDB entry 1j1d, assembly 1, front view.
Troponin I, cardiac muscle in PDB entry 1j1d, assembly 1, side view.
Troponin I, cardiac muscle in PDB entry 1j1d, assembly 1, top view.
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