1j1c Summary


Binary complex structure of human tau protein kinase I with ADP

The structure was published by Aoki, M., Yokota, T., Sugiura, I., et al., Kohno, T., Sugio, S., and Matsuzaki, T., in 2004 in a paper entitled "Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) ATP bindingsearch NF-kappaB bindingsearch protein bindingsearch beta-catenin bindingsearch tau protein bindingsearch kinase activitysearch tau-protein kinase activitysearch RNA polymerase II transcription factor bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch p53 bindingsearch protein kinase bindingsearch transferase activitysearch protein kinase A catalytic subunit bindingsearch integrin bindingsearch ionotropic glutamate receptor bindingsearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch peptidyl-serine phosphorylationsearch carbohydrate metabolic processsearch hypermethylation of CpG islandsearch response to drugsearch protein phosphorylationsearch positive regulation of peptidyl-threonine phosphorylationsearch cell differentiationsearch cellular response to mechanical stimulussearch organ morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch positive regulation of protein catabolic processsearch phosphorylationsearch circadian rhythmsearch ER overload responsesearch cellular response to interleukin-3search extrinsic apoptotic signaling pathway in absence of ligandsearch superior temporal gyrus developmentsearch regulation of neuronal synaptic plasticitysearch regulation of gene expression by genetic imprintingsearch re-entry into mitotic cell cyclesearch negative regulation of cardiac muscle hypertrophysearch myotube differentiationsearch negative regulation of NFAT protein import into nucleussearch canonical Wnt signaling pathwaysearch nervous system developmentsearch negative regulation of neuron projection developmentsearch negative regulation of type B pancreatic cell developmentsearch positive regulation of stem cell differentiationsearch protein export from nucleussearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of protein complex assemblysearch multicellular organismal developmentsearch negative regulation of neuron maturationsearch positive regulation of protein bindingsearch positive regulation of cell-matrix adhesionsearch regulation of microtubule-based processsearch positive regulation of protein export from nucleussearch positive regulation of Rac GTPase activitysearch Wnt signaling pathwaysearch positive regulation of apoptotic processsearch phosphatidylinositol-mediated signalingsearch negative regulation of dendrite morphogenesissearch hippocampus developmentsearch establishment of cell polaritysearch positive regulation of protein complex assemblysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of signal transductionsearch epidermal growth factor receptor signaling pathwaysearch negative regulation of protein bindingsearch glycogen metabolic processsearch response to lithium ionsearch establishment or maintenance of cell polaritysearch intracellular signal transductionsearch innate immune responsesearch negative regulation of apoptotic processsearch rhythmic processsearch cell migrationsearch Fc-epsilon receptor signaling pathwaysearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch epithelial to mesenchymal transitionsearch positive regulation of peptidyl-serine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of MAP kinase activitysearch negative regulation of glycogen (starch) synthase activitysearch protein localization to microtubulesearch fat cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch axon guidancesearch myoblast fusionsearch axonogenesissearch cytosolsearch cytoplasmsearch membranesearch plasma membranesearch membrane-bounded organellesearch centrosomesearch nucleussearch dendritic spinesearch protein complexsearch membrane raftsearch dendritic shaftsearch beta-catenin destruction complexsearch neuronal cell bodysearch ribonucleoprotein complexsearch cell bodysearch growth conesearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch