1j1b Summary


Binary complex structure of human tau protein kinase I with AMPPNP

The structure was published by Aoki, M., Yokota, T., Sugiura, I., et al., Kohno, T., Sugio, S., and Matsuzaki, T., in 2004 in a paper entitled "Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein kinase activitysearch protein bindingsearch tau-protein kinase activitysearch integrin bindingsearch kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch tau protein bindingsearch protein kinase A catalytic subunit bindingsearch transferase activity, transferring phosphorus-containing groupssearch NF-kappaB bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch RNA polymerase II transcription factor bindingsearch beta-catenin bindingsearch protein kinase bindingsearch p53 bindingsearch nucleotide bindingsearch ionotropic glutamate receptor bindingsearch negative regulation of protein complex assemblysearch extrinsic apoptotic signaling pathway in absence of ligandsearch response to drugsearch positive regulation of stem cell differentiationsearch negative regulation of type B pancreatic cell developmentsearch negative regulation of apoptotic processsearch canonical Wnt signaling pathwaysearch positive regulation of protein complex assemblysearch fibroblast growth factor receptor signaling pathwaysearch myoblast fusionsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch protein localization to microtubulesearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch positive regulation of protein export from nucleussearch negative regulation of dendrite morphogenesissearch protein phosphorylationsearch negative regulation of MAP kinase activitysearch regulation of gene expression by genetic imprintingsearch protein export from nucleussearch glycogen metabolic processsearch intracellular signal transductionsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of cardiac muscle hypertrophysearch superior temporal gyrus developmentsearch peptidyl-serine phosphorylationsearch regulation of neuronal synaptic plasticitysearch regulation of neuron projection developmentsearch fat cell differentiationsearch circadian rhythmsearch cellular response to heatsearch Wnt signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch regulation of microtubule-based processsearch multicellular organismal developmentsearch positive regulation of canonical Wnt signaling pathwaysearch positive regulation of cell-matrix adhesionsearch phosphorylationsearch negative regulation of neuron maturationsearch ER overload responsesearch positive regulation of protein catabolic processsearch epidermal growth factor receptor signaling pathwaysearch axon guidancesearch positive regulation of protein bindingsearch axonogenesissearch positive regulation of Rac GTPase activitysearch nervous system developmentsearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of signal transductionsearch organ morphogenesissearch cellular response to interleukin-3search negative regulation of NFAT protein import into nucleussearch response to lithium ionsearch positive regulation of axon extensionsearch establishment or maintenance of cell polaritysearch cell migrationsearch innate immune responsesearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of neuron projection developmentsearch epithelial to mesenchymal transitionsearch negative regulation of protein bindingsearch phosphatidylinositol-mediated signalingsearch neurotrophin TRK receptor signaling pathwaysearch establishment of cell polaritysearch re-entry into mitotic cell cyclesearch rhythmic processsearch hippocampus developmentsearch carbohydrate metabolic processsearch regulation of cellular response to heatsearch positive regulation of apoptotic processsearch myotube differentiationsearch hypermethylation of CpG islandsearch cell differentiationsearch cellular response to mechanical stimulussearch positive regulation of peptidyl-serine phosphorylationsearch cytosolsearch nucleussearch plasma membranesearch cytoplasmsearch beta-catenin destruction complexsearch membrane-bounded organellesearch dendritic shaftsearch membranesearch growth conesearch ribonucleoprotein complexsearch neuronal cell bodysearch dendritic spinesearch centrosomesearch nucleoplasmsearch cell bodysearch protein complexsearch membrane raftsearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch