1j1b Summary


Binary complex structure of human tau protein kinase I with AMPPNP

The structure was published by Aoki, M., Yokota, T., Sugiura, I., et al., Kohno, T., Sugio, S., and Matsuzaki, T., in 2004 in a paper entitled "Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch tau-protein kinase activitysearch protein bindingsearch kinase activitysearch beta-catenin bindingsearch NF-kappaB bindingsearch ubiquitin protein ligase bindingsearch RNA polymerase II transcription factor bindingsearch p53 bindingsearch ionotropic glutamate receptor bindingsearch protein kinase bindingsearch nucleotide bindingsearch transferase activitysearch tau protein bindingsearch integrin bindingsearch protein kinase A catalytic subunit bindingsearch protein phosphorylationsearch glycogen metabolic processsearch ER overload responsesearch positive regulation of Rac GTPase activitysearch negative regulation of signal transductionsearch negative regulation of glycogen (starch) synthase activitysearch protein export from nucleussearch multicellular organismal developmentsearch positive regulation of cell-matrix adhesionsearch regulation of gene expression by genetic imprintingsearch negative regulation of cardiac muscle hypertrophysearch regulation of microtubule-based processsearch extrinsic apoptotic signaling pathway in absence of ligandsearch Wnt signaling pathwaysearch positive regulation of protein catabolic processsearch positive regulation of apoptotic processsearch Fc-epsilon receptor signaling pathwaysearch re-entry into mitotic cell cyclesearch peptidyl-serine phosphorylationsearch circadian rhythmsearch cell differentiationsearch cellular response to interleukin-3search negative regulation of NFAT protein import into nucleussearch neurotrophin TRK receptor signaling pathwaysearch myoblast fusionsearch organ morphogenesissearch positive regulation of protein bindingsearch negative regulation of apoptotic processsearch epithelial to mesenchymal transitionsearch negative regulation of protein bindingsearch positive regulation of peptidyl-serine phosphorylationsearch hippocampus developmentsearch canonical Wnt signaling pathwaysearch positive regulation of stem cell differentiationsearch rhythmic processsearch protein localization to microtubulesearch regulation of neuronal synaptic plasticitysearch positive regulation of protein export from nucleussearch negative regulation of glycogen biosynthetic processsearch negative regulation of dendrite morphogenesissearch establishment of cell polaritysearch response to lithium ionsearch fat cell differentiationsearch response to drugsearch negative regulation of canonical Wnt signaling pathwaysearch axon guidancesearch innate immune responsesearch phosphatidylinositol-mediated signalingsearch positive regulation of transcription from RNA polymerase II promotersearch nervous system developmentsearch negative regulation of protein complex assemblysearch positive regulation of protein complex assemblysearch cellular response to mechanical stimulussearch negative regulation of MAP kinase activitysearch negative regulation of type B pancreatic cell developmentsearch fibroblast growth factor receptor signaling pathwaysearch carbohydrate metabolic processsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch epidermal growth factor receptor signaling pathwaysearch phosphorylationsearch positive regulation of peptidyl-threonine phosphorylationsearch hypermethylation of CpG islandsearch cell migrationsearch intracellular signal transductionsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch myotube differentiationsearch establishment or maintenance of cell polaritysearch superior temporal gyrus developmentsearch axonogenesissearch nucleussearch centrosomesearch protein complexsearch ribonucleoprotein complexsearch cytosolsearch plasma membranesearch cytoplasmsearch perinuclear region of cytoplasmsearch membranesearch membrane raftsearch beta-catenin destruction complexsearch neuronal cell bodysearch growth conesearch membrane-bounded organellesearch dendritic spinesearch dendritic shaftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch