1izb Summary

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ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Bentley, G.A., Brange, J., Derewenda, Z., et al., Wilkinson, A.J., Wollmer, A., and Xiao, B., in 1992 in a paper entitled "Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
C INSULIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
B INSULIN P01315 (25-53) (INS_PIG)search Sus scrofasearch < 90% 30 100%
D INSULIN P01315 (25-53) (INS_PIG)search Sus scrofasearch < 90% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01315 (88 - 108) INSULIN Sus scrofa

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C Insulin-likesearch Insulin/IGF/Relaxin familysearch
B, D Insulin-likesearch Insulin/IGF/Relaxin familysearch

Chain ID Cellular component (GO) Molecular function (GO)
A, C (P01315) extracellular regionsearch hormone activitysearch
B, D (P01315) extracellular regionsearch hormone activitysearch

Chain InterPro annotation
A, C Insulin-likesearch Insulin, conserved sitesearch
B, D Insulinsearch Insulin-likesearch