1iyt Summary


Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)

The structure was published by Crescenzi, O., Tomaselli, S., Guerrini, R., et al., D'Ursi, A.M., Temussi, P.A., and Picone, D., in 2002 in a paper entitled "Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Alzheimer's disease amyloid. This molecule has the UniProt identifier P05067 (A4_HUMAN)search. The sample contained 42 residues which is < 90% of the natural sequence. Out of 42 residues 42 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alzheimer's disease amyloid P05067 (672-713) (A4_HUMAN)search Homo sapienssearch < 90% 42 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05067 (672 - 713) Alzheimer's disease amyloid

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Amyloid peptidessearch Amyloid A4search Beta-amyloid peptide (beta-APP)search

Chain ID Biological process (GO) Cellular component (GO)
A (P05067) nervous system developmentsearch integral component of membranesearch

Chain InterPro annotation
A Amyloidogenic glycoprotein, amyloid-beta peptidesearch Amyloid beta A4 proteinsearch