1iyj › Citations

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP
Science 297 1837-48 (2002)
Related entries: 1miu, 1mje

Cited: 435 times
EuropePMC logo PMID: 12228710

Abstract

Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif. We also (i) demonstrate that this BRCA2 domain binds single-stranded DNA, (ii) present its 3.5 angstrom structure bound to oligo(dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 stimulates RAD51-mediated recombination in vitro. These findings establish that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCA2-associated cancers.

Reviews - 1iyj mentioned but not cited (4)

  1. Nucleic acid recognition by OB-fold proteins. Theobald DL, Mitton-Fry RM, Wuttke DS. Annu Rev Biophys Biomol Struct 32 115-133 (2003)
  2. The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination. Zhao W, Wiese C, Kwon Y, Hromas R, Sung P. Annu Rev Biochem 88 221-245 (2019)
  3. Roles of OB-Fold Proteins in Replication Stress. Nguyen DD, Kim EY, Sang PB, Chai W. Front Cell Dev Biol 8 574466 (2020)
  4. The phospho-dependent role of BRCA2 on the maintenance of chromosome integrity. Ehlén Å, Sessa G, Zinn-Justin S, Carreira A. Cell Cycle 20 731-741 (2021)

Articles - 1iyj mentioned but not cited (9)

  1. Classifying Variants of Undetermined Significance in BRCA2 with protein likelihood ratios. Karchin R, Agarwal M, Sali A, Couch F, Beattie MS. Cancer Inform 6 203-216 (2008)
  2. Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance. Lee M, Shorthouse D, Mahen R, Hall BA, Venkitaraman AR. Nucleic Acids Res 49 5588-5604 (2021)
  3. Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair. Paul MW, Sidhu A, Liang Y, van Rossum-Fikkert SE, Odijk H, Zelensky AN, Kanaar R, Wyman C. Elife 10 e67926 (2021)
  4. Impact of structural prior knowledge in SNV prediction: Towards causal variant finding in rare disease. Dehiya V, Thomas J, Sael L. PLoS One 13 e0204101 (2018)
  5. Molecular characterization, homology modeling and docking studies of the R2787H missense variation in BRCA2 gene: Association with breast cancer. Riahi A, Messaoudi A, Mrad R, Fourati A, Chabouni-Bouhamed H, Kharrat M. J Theor Biol 403 188-196 (2016)
  6. The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus. Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. Front Genet 13 884210 (2022)
  7. A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma. Krishnamurthy K, Oh KS, Alghamdi S, Sriganeshan V, Poppiti R. Pleura Peritoneum 8 19-25 (2023)
  8. Computational Biology of BRCA2 in Male Breast Cancer, through Prediction of Probable nsSNPs, and Hit Identification. Shinde SD, Satpute DP, Behera SK, Kumar D. ACS Omega 7 30447-30461 (2022)
  9. Towards a New, Endophenotype-Based Strategy for Pathogenicity Prediction in BRCA1 and BRCA2: In Silico Modeling of the Outcome of HDR/SGE Assays for Missense Variants. Özkan S, Padilla N, de la Cruz X. Int J Mol Sci 22 6226 (2021)


Reviews citing this publication (131)

  1. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Annu Rev Biochem 73 39-85 (2004)
  2. ATM and related protein kinases: safeguarding genome integrity. Shiloh Y. Nat Rev Cancer 3 155-168 (2003)
  3. Mechanism of eukaryotic homologous recombination. San Filippo J, Sung P, Klein H. Annu Rev Biochem 77 229-257 (2008)
  4. Regulation of DNA double-strand break repair pathway choice. Shrivastav M, De Haro LP, Nickoloff JA. Cell Res 18 134-147 (2008)
  5. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Roy R, Chun J, Powell SN. Nat Rev Cancer 12 68-78 (2011)
  6. Molecular views of recombination proteins and their control. West SC. Nat Rev Mol Cell Biol 4 435-445 (2003)
  7. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Moynahan ME, Jasin M. Nat Rev Mol Cell Biol 11 196-207 (2010)
  8. The Fanconi anaemia/BRCA pathway. D'Andrea AD, Grompe M. Nat Rev Cancer 3 23-34 (2003)
  9. Homologous recombination in DNA repair and DNA damage tolerance. Li X, Heyer WD. Cell Res 18 99-113 (2008)
  10. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. Ashworth A. J Clin Oncol 26 3785-3790 (2008)
  11. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Wang W. Nat Rev Genet 8 735-748 (2007)
  12. Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Prakash R, Zhang Y, Feng W, Jasin M. Cold Spring Harb Perspect Biol 7 a016600 (2015)
  13. The many faces of the helix-turn-helix domain: transcription regulation and beyond. Aravind L, Anantharaman V, Balaji S, Babu MM, Iyer LM. FEMS Microbiol Rev 29 231-262 (2005)
  14. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Sung P, Klein H. Nat Rev Mol Cell Biol 7 739-750 (2006)
  15. How the fanconi anemia pathway guards the genome. Moldovan GL, D'Andrea AD. Annu Rev Genet 43 223-249 (2009)
  16. Regulation and mechanisms of mammalian double-strand break repair. Valerie K, Povirk LF. Oncogene 22 5792-5812 (2003)
  17. Homologous recombination and its regulation. Krejci L, Altmannova V, Spirek M, Zhao X. Nucleic Acids Res 40 5795-5818 (2012)
  18. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV, Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, Gogarten SM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, Lemire M, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD, Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO, Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, Zeng YX, Zhang B, Zheng W, Hsu L, Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium. Gastroenterology 144 799-807.e24 (2013)
  19. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Thompson LH. Mutat Res 751 158-246 (2012)
  20. Susceptibility pathways in Fanconi's anemia and breast cancer. D'Andrea AD. N Engl J Med 362 1909-1919 (2010)
  21. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Jasin M. Oncogene 21 8981-8993 (2002)
  22. Collaboration and competition between DNA double-strand break repair pathways. Kass EM, Jasin M. FEBS Lett 584 3703-3708 (2010)
  23. Plasmodium biology: genomic gleanings. Aravind L, Iyer LM, Wellems TE, Miller LH. Cell 115 771-785 (2003)
  24. Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation. Powell SN, Kachnic LA. Oncogene 22 5784-5791 (2003)
  25. DNA strand break repair and human genetic disease. McKinnon PJ, Caldecott KW. Annu Rev Genomics Hum Genet 8 37-55 (2007)
  26. The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Tutt A, Ashworth A. Trends Mol Med 8 571-576 (2002)
  27. From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold. Bochkarev A, Bochkareva E. Curr Opin Struct Biol 14 36-42 (2004)
  28. Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes. Ranjha L, Howard SM, Cejka P. Chromosoma 127 187-214 (2018)
  29. Oncogenes and tumor suppressor genes. Lee EY, Muller WJ. Cold Spring Harb Perspect Biol 2 a003236 (2010)
  30. Assembly, structure, and function of the 26S proteasome. Bedford L, Paine S, Sheppard PW, Mayer RJ, Roelofs J. Trends Cell Biol 20 391-401 (2010)
  31. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Venkitaraman AR. Annu Rev Pathol 4 461-487 (2009)
  32. The DNA damage response pathways: at the crossroad of protein modifications. Huen MS, Chen J. Cell Res 18 8-16 (2008)
  33. Replication protein A: directing traffic at the intersection of replication and repair. Oakley GG, Patrick SM. Front Biosci (Landmark Ed) 15 883-900 (2010)
  34. Tracing the network connecting BRCA and Fanconi anaemia proteins. Venkitaraman AR. Nat Rev Cancer 4 266-276 (2004)
  35. Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Flynn RL, Zou L. Crit Rev Biochem Mol Biol 45 266-275 (2010)
  36. Shieldin - the protector of DNA ends. Setiaputra D, Durocher D. EMBO Rep 20 e47560 (2019)
  37. Unraveling the mechanism of BRCA2 in homologous recombination. Holloman WK. Nat Struct Mol Biol 18 748-754 (2011)
  38. BRCA2: a universal recombinase regulator. Thorslund T, West SC. Oncogene 26 7720-7730 (2007)
  39. Rho-associated coiled-coil kinase (ROCK) signaling and disease. Schofield AV, Bernard O. Crit Rev Biochem Mol Biol 48 301-316 (2013)
  40. DNA damage response--a double-edged sword in cancer prevention and cancer therapy. Tian H, Gao Z, Li H, Zhang B, Wang G, Zhang Q, Pei D, Zheng J. Cancer Lett 358 8-16 (2015)
  41. Regulation of DNA strand exchange in homologous recombination. Holthausen JT, Wyman C, Kanaar R. DNA Repair (Amst) 9 1264-1272 (2010)
  42. PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika. Pick E, Hofmann K, Glickman MH. Mol Cell 35 260-264 (2009)
  43. Choreography of recombination proteins during the DNA damage response. Lisby M, Rothstein R. DNA Repair (Amst) 8 1068-1076 (2009)
  44. The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. Crossan GP, Patel KJ. J Pathol 226 326-337 (2012)
  45. How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery. Thompson LH, Hinz JM, Yamada NA, Jones NJ. Environ Mol Mutagen 45 128-142 (2005)
  46. RAD51, genomic stability, and tumorigenesis. Richardson C. Cancer Lett 218 127-139 (2005)
  47. Single-stranded DNA-binding proteins: multiple domains for multiple functions. Dickey TH, Altschuler SE, Wuttke DS. Structure 21 1074-1084 (2013)
  48. Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis. Richard DJ, Bolderson E, Khanna KK. Crit Rev Biochem Mol Biol 44 98-116 (2009)
  49. Functional assays for analysis of variants of uncertain significance in BRCA2. Guidugli L, Carreira A, Caputo SM, Ehlen A, Galli A, Monteiro AN, Neuhausen SL, Hansen TV, Couch FJ, Vreeswijk MP, ENIGMA consortium. Hum Mutat 35 151-164 (2014)
  50. The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans. Moynahan ME. Oncogene 21 8994-9007 (2002)
  51. Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective. Sandhu SK, Yap TA, de Bono JS. Eur J Cancer 46 9-20 (2010)
  52. Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. Nagaraju G, Scully R. DNA Repair (Amst) 6 1018-1031 (2007)
  53. The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Paul A, Paul S. Front Biosci (Landmark Ed) 19 605-618 (2014)
  54. Disordered proteinaceous machines. Fuxreiter M, Tóth-Petróczy Á, Kraut DA, Matouschek A, Lim RY, Xue B, Kurgan L, Uversky VN. Chem Rev 114 6806-6843 (2014)
  55. Structural biology of innate immunity. Yin Q, Fu TM, Li J, Wu H. Annu Rev Immunol 33 393-416 (2015)
  56. DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing. Xue C, Greene EC. Trends Genet 37 639-656 (2021)
  57. Links between DNA double strand break repair and breast cancer: accumulating evidence from both familial and nonfamilial cases. Ralhan R, Kaur J, Kreienberg R, Wiesmüller L. Cancer Lett 248 1-17 (2007)
  58. BRCA mutation in ovarian cancer: testing, implications and treatment considerations. Neff RT, Senter L, Salani R. Ther Adv Med Oncol 9 519-531 (2017)
  59. Role of BRCA Mutations in the Modulation of Response to Platinum Therapy. Mylavarapu S, Das A, Roy M. Front Oncol 8 16 (2018)
  60. Structural basis of homologous recombination. Sun Y, McCorvie TJ, Yates LA, Zhang X. Cell Mol Life Sci 77 3-18 (2020)
  61. Genomic instability and cancer: networks involved in response to DNA damage. Eyfjord JE, Bodvarsdottir SK. Mutat Res 592 18-28 (2005)
  62. DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2. Shivji MK, Venkitaraman AR. DNA Repair (Amst) 3 835-843 (2004)
  63. RAD51 Gene Family Structure and Function. Bonilla B, Hengel SR, Grundy MK, Bernstein KA. Annu Rev Genet 54 25-46 (2020)
  64. Overall Survival and Clinical Characteristics of BRCA-Associated Cholangiocarcinoma: A Multicenter Retrospective Study. Golan T, Raitses-Gurevich M, Kelley RK, Bocobo AG, Borgida A, Shroff RT, Holter S, Gallinger S, Ahn DH, Aderka D, Apurva J, Bekaii-Saab T, Friedman E, Javle M. Oncologist 22 804-810 (2017)
  65. PALB2: the hub of a network of tumor suppressors involved in DNA damage responses. Park JY, Zhang F, Andreassen PR. Biochim Biophys Acta 1846 263-275 (2014)
  66. Human single-stranded DNA binding proteins are essential for maintaining genomic stability. Ashton NW, Ashton NW, Bolderson E, Cubeddu L, O'Byrne KJ, Richard DJ. BMC Mol Biol 14 9 (2013)
  67. Fanconi anemia. Green AM, Kupfer GM. Hematol Oncol Clin North Am 23 193-214 (2009)
  68. Single-molecule imaging brings Rad51 nucleoprotein filaments into focus. Forget AL, Kowalczykowski SC. Trends Cell Biol 20 269-276 (2010)
  69. Structure and function of the double-strand break repair machinery. Shin DS, Chahwan C, Huffman JL, Tainer JA. DNA Repair (Amst) 3 863-873 (2004)
  70. Role of homologous recombination in DNA interstrand crosslink repair. Hinz JM. Environ Mol Mutagen 51 582-603 (2010)
  71. The homologous recombination system of Ustilago maydis. Holloman WK, Schirawski J, Holliday R. Fungal Genet Biol 45 Suppl 1 S31-9 (2008)
  72. BRCA gene structure and function in tumor suppression: a repair-centric perspective. Murphy CG, Moynahan ME. Cancer J 16 39-47 (2010)
  73. Cell biology of mitotic recombination. Lisby M, Rothstein R. Cold Spring Harb Perspect Biol 7 a016535 (2015)
  74. Dual role of CDKs in DNA repair: to be, or not to be. Yata K, Esashi F. DNA Repair (Amst) 8 6-18 (2009)
  75. Localization of checkpoint and repair proteins in eukaryotes. Lisby M, Rothstein R. Biochimie 87 579-589 (2005)
  76. Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network. Greenberg RA. Chromosoma 117 305-317 (2008)
  77. The Fanconi anemia pathway and ubiquitin. Jacquemont C, Taniguchi T. BMC Biochem 8 Suppl 1 S10 (2007)
  78. A growing network of cancer-susceptibility genes. Venkitaraman AR. N Engl J Med 348 1917-1919 (2003)
  79. Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention. Gasch C, Ffrench B, O'Leary JJ, Gallagher MF. Mol Cancer 16 43 (2017)
  80. The interplay of Fanconi anemia proteins in the DNA damage response. Wang X, D'Andrea AD. DNA Repair (Amst) 3 1063-1069 (2004)
  81. The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy. Motegi A, Murakawa Y, Takeda S. Cancer Lett 283 1-9 (2009)
  82. BRCA2 functions: from DNA repair to replication fork stabilization. Fradet-Turcotte A, Sitz J, Grapton D, Orthwein A. Endocr Relat Cancer 23 T1-T17 (2016)
  83. Ontologies for proteomics: towards a systematic definition of structure and function that scales to the genome level. Lan N, Montelione GT, Gerstein M. Curr Opin Chem Biol 7 44-54 (2003)
  84. The DNA double-strand break response pathway: becoming more BRCAish than ever. Ting NS, Lee WH. DNA Repair (Amst) 3 935-944 (2004)
  85. The development of PARP inhibitors in ovarian cancer: from bench to bedside. Drew Y. Br J Cancer 113 Suppl 1 S3-9 (2015)
  86. BRCA2 and pancreatic cancer. Naderi A, Couch FJ. Int J Gastrointest Cancer 31 99-106 (2002)
  87. From meiosis to postmeiotic events: uncovering the molecular roles of the meiosis-specific recombinase Dmc1. Kagawa W, Kurumizaka H. FEBS J 277 590-598 (2010)
  88. How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility? Venkitaraman AR. DNA Repair (Amst) 81 102668 (2019)
  89. Structural biology of the PCI-protein fold. Ellisdon AM, Stewart M. Bioarchitecture 2 118-123 (2012)
  90. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen CC. Future Oncol 7 1335-1346 (2011)
  91. Quality control of homologous recombination. Liu T, Huang J. Cell Mol Life Sci 71 3779-3797 (2014)
  92. Single nucleotide polymorphisms in DNA repair genes and putative cancer risk. Köberle B, Koch B, Fischer BM, Hartwig A. Arch Toxicol 90 2369-2388 (2016)
  93. DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment. Toland AE, Andreassen PR. J Med Genet 54 721-731 (2017)
  94. From systems to structure: bridging networks and mechanism. Fraser JS, Gross JD, Krogan NJ. Mol Cell 49 222-231 (2013)
  95. Meiotic recombination in Caenorhabditis elegans. Garcia-Muse T, Boulton SJ. Chromosome Res 15 607-621 (2007)
  96. Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer. Hollis RL, Churchman M, Gourley C. Onco Targets Ther 10 2539-2551 (2017)
  97. Exploring the roles of PALB2 at the crossroads of DNA repair and cancer. Pauty J, Rodrigue A, Couturier A, Buisson R, Masson JY. Biochem J 460 331-342 (2014)
  98. Genetic variations in colorectal cancer risk and clinical outcome. Zhang K, Civan J, Mukherjee S, Patel F, Yang H. World J Gastroenterol 20 4167-4177 (2014)
  99. Breast cancer susceptibility testing: past, present and future. Goldberg JI, Borgen PI. Expert Rev Anticancer Ther 6 1205-1214 (2006)
  100. Structural disorder and its role in proteasomal degradation. Aufderheide A, Unverdorben P, Baumeister W, Förster F. FEBS Lett 589 2552-2560 (2015)
  101. Molecular Trajectory of BRCA1 and BRCA2 Mutations. Hatano Y, Tamada M, Matsuo M, Hara A. Front Oncol 10 361 (2020)
  102. Defects in homologous recombination repair behind the human diseases: FA and HBOC. Katsuki Y, Takata M. Endocr Relat Cancer 23 T19-37 (2016)
  103. Cycling with BRCA2 from DNA repair to mitosis. Lee H. Exp Cell Res 329 78-84 (2014)
  104. Genetic instability in inherited and sporadic leukemias. Popp HD, Bohlander SK. Genes Chromosomes Cancer 49 1071-1081 (2010)
  105. Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches. Farolfi A, Gurioli G, Fugazzola P, Burgio SL, Casanova C, Ravaglia G, Altavilla A, Costantini M, Amadori A, Framarini M, Ansaloni L, De Giorgi U. Int J Mol Sci 20 E2569 (2019)
  106. Molding BRCA2 function through its interacting partners. Martinez JS, Baldeyron C, Carreira A. Cell Cycle 14 3389-3395 (2015)
  107. Advances in structural studies of recombination mediator proteins. Korolev S. Biophys Chem 225 27-37 (2017)
  108. Misrepair in Context: TGFβ Regulation of DNA Repair. Liu Q, Lopez K, Murnane J, Humphrey T, Barcellos-Hoff MH. Front Oncol 9 799 (2019)
  109. Guardians of the Genome: BRCA2 and Its Partners. Le HP, Heyer WD, Liu J. Genes (Basel) 12 1229 (2021)
  110. Multiple interlinked mechanisms to circumvent DNA replication roadblocks. Eppink B, Wyman C, Kanaar R. Exp Cell Res 312 2660-2665 (2006)
  111. Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses. Andreassen PR, Seo J, Wiek C, Hanenberg H. Genes (Basel) 12 1034 (2021)
  112. HRness in Breast and Ovarian Cancers. Santana Dos Santos E, Lallemand F, Petitalot A, Caputo SM, Rouleau E. Int J Mol Sci 21 E3850 (2020)
  113. Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Shin DS, Pratt AJ, Tainer JA. Archaea 2014 206735 (2014)
  114. Synthetic lethality: the road to novel therapies for breast cancer. Dhillon KK, Bajrami I, Taniguchi T, Lord CJ. Endocr Relat Cancer 23 T39-55 (2016)
  115. BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis. Li Q, Engebrecht J. Front Cell Dev Biol 9 668309 (2021)
  116. BRCA2 in meiosis: turning over a new leaf. Gudmundsdottir K, Ashworth A. Trends Cell Biol 14 401-404 (2004)
  117. Homologous Recombination in Protozoan Parasites and Recombinase Inhibitors. Kelso AA, Waldvogel SM, Luthman AJ, Sehorn MG. Front Microbiol 8 1716 (2017)
  118. Biochemical attributes of mitotic and meiotic presynaptic complexes. Crickard JB, Greene EC. DNA Repair (Amst) 71 148-157 (2018)
  119. Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules. Jimenez-Sainz J, Jensen RB. Genes (Basel) 12 780 (2021)
  120. The Genetic Analyses of French Canadians of Quebec Facilitate the Characterization of New Cancer Predisposing Genes Implicated in Hereditary Breast and/or Ovarian Cancer Syndrome Families. Fierheller CT, Alenezi WM, Tonin PN. Cancers (Basel) 13 3406 (2021)
  121. The role of the Fanconi anemia network in the response to DNA replication stress. Gari K, Constantinou A. Crit Rev Biochem Mol Biol 44 292-325 (2009)
  122. BRCA2: one small step for DNA repair, one giant protein purified. Jensen RB. Yale J Biol Med 86 479-489 (2013)
  123. Repair of DNA double-strand breaks in plant meiosis: role of eukaryotic RecA recombinases and their modulators. Emmenecker C, Mézard C, Kumar R. Plant Reprod 36 17-41 (2023)
  124. Roles of homologous recombination in response to ionizing radiation-induced DNA damage. Nickoloff JA, Sharma N, Allen CP, Taylor L, Allen SJ, Jaiswal AS, Hromas R. Int J Radiat Biol 99 903-914 (2023)
  125. Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events. Julien M, Ghouil R, Petitalot A, Caputo SM, Carreira A, Zinn-Justin S. Biomolecules 11 1060 (2021)
  126. OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block. Bianco PR. Front Mol Biosci 9 784451 (2022)
  127. [Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair]. Buisson R, Masson JY. Med Sci (Paris) 29 301-307 (2013)
  128. [Genetic bases of the radiosensitivity of breast cancer]. Delaloge S, Marsiglia H. Cancer Radiother 9 77-86 (2005)
  129. BRCA Mutations-The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers. Loboda AP, Adonin LS, Zvereva SD, Guschin DY, Korneenko TV, Telegina AV, Kondratieva OK, Frolova SE, Pestov NB, Barlev NA. Int J Mol Sci 24 4982 (2023)
  130. Missense Variants of Uncertain Significance: A Powerful Genetic Tool for Function Discovery with Clinical Implications. Sessa G, Ehlén Å, von Nicolai C, Carreira A. Cancers (Basel) 13 3719 (2021)
  131. Progress and prospects in research and clinical practice of hormone receptor-positive, HER-2-negative breast cancer with BRCA1/2 mutations. Yan S, Imam M. Discov Oncol 14 110 (2023)

Articles citing this publication (291)

  1. Resistance to therapy caused by intragenic deletion in BRCA2. Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Nature 451 1111-1115 (2008)
  2. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM. Mol Cell 22 719-729 (2006)
  3. Purified human BRCA2 stimulates RAD51-mediated recombination. Jensen RB, Carreira A, Kowalczykowski SC. Nature 467 678-683 (2010)
  4. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M. Mol Cell Biol 24 9305-9316 (2004)
  5. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC. Nature 434 598-604 (2005)
  6. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Lei M, Podell ER, Cech TR. Nat Struct Mol Biol 11 1223-1229 (2004)
  7. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Bhatia V, Barroso SI, García-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A. Nature 511 362-365 (2014)
  8. A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. Easton DF, Deffenbaugh AM, Pruss D, Frye C, Wenstrup RJ, Allen-Brady K, Tavtigian SV, Monteiro AN, Iversen ES, Couch FJ, Goldgar DE. Am J Hum Genet 81 873-883 (2007)
  9. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R. Cell 123 265-276 (2005)
  10. Factors determining DNA double-strand break repair pathway choice in G2 phase. Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA. EMBO J 30 1079-1092 (2011)
  11. Improved survival in women with BRCA-associated ovarian carcinoma. Cass I, Baldwin RL, Varkey T, Moslehi R, Narod SA, Karlan BY. Cancer 97 2187-2195 (2003)
  12. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD, Wang ZQ, Jasin M. Proc Natl Acad Sci U S A 102 1110-1115 (2005)
  13. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Liu J, Doty T, Gibson B, Heyer WD. Nat Struct Mol Biol 17 1260-1262 (2010)
  14. Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2. Goldgar DE, Easton DF, Deffenbaugh AM, Monteiro AN, Tavtigian SV, Couch FJ, Breast Cancer Information Core (BIC) Steering Committee. Am J Hum Genet 75 535-544 (2004)
  15. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL, CIMBA Consortium, Laitman Y, Kushnir A, Paluch-Shimon S, Berger R, Zidan J, Friedman E, Ehrencrona H, Stenmark-Askmalm M, Einbeigi Z, Loman N, Harbst K, Rantala J, Melin B, Huo D, Olopade OI, Seldon J, Ganz PA, Nussbaum RL, Chan SB, Odunsi K, Gayther SA, Domchek SM, Arun BK, Lu KH, Mitchell G, Karlan BY, Walsh C, Lester J, Godwin AK, Pathak H, Ross E, Daly MB, Whittemore AS, John EM, Miron A, Terry MB, Chung WK, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Steele L, Neuhausen SL, Ding YC, Ejlertsen B, Gerdes AM, Hansen Tv, Ramón y Cajal T, Osorio A, Benitez J, Godino J, Tejada MI, Duran M, Weitzel JN, Bobolis KA, Sand SR, Fontaine A, Savarese A, Pasini B, Peissel B, Bonanni B, Zaffaroni D, Vignolo-Lutati F, Scuvera G, Giannini G, Bernard L, Genuardi M, Radice P, Dolcetti R, Manoukian S, Pensotti V, Gismondi V, Yannoukakos D, Fostira F, Garber J, Torres D, Rashid MU, Hamann U, Peock S, Frost D, Platte R, Evans DG, Eeles R, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Izatt L, Adlard J, Donaldson A, Ellis S, Sharma P, Schmutzler RK, Wappenschmidt B, Becker A, Rhiem K, Hahnen E, Engel C, Meindl A, Engert S, Ditsch N, Arnold N, Plendl HJ, Mundhenke C, Niederacher D, Fleisch M, Sutter C, Bartram CR, Dikow N, Wang-Gohrke S, Gadzicki D, Steinemann D, Kast K, Beer M, Varon-Mateeva R, Gehrig A, Weber BH, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Houdayer C, Belotti M, Gauthier-Villars M, Damiola F, Boutry-Kryza N, Lasset C, Sobol H, Peyrat JP, Muller D, Fricker JP, Collonge-Rame MA, Mortemousque I, Nogues C, Rouleau E, Isaacs C, De Paepe A, Poppe B, Claes K, De Leeneer K, Piedmonte M, Rodriguez G, Wakely K, Boggess J, Blank SV, Basil J, Azodi M, Phillips KA, Caldes T, de la Hoya M, Romero A, Nevanlinna H, Aittomäki K, van der Hout AH, Hogervorst FB, Verhoef S, Collée JM, Seynaeve C, Oosterwijk JC, Gille JJ, Wijnen JT, Gómez Garcia EB, Kets CM, Ausems MG, Aalfs CM, Devilee P, Mensenkamp AR, Kwong A, Olah E, Papp J, Diez O, Lazaro C, Darder E, Blanco I, Salinas M, Jakubowska A, Lubinski J, Gronwald J, Jaworska-Bieniek K, Durda K, Sukiennicki G, Huzarski T, Byrski T, Cybulski C, Toloczko-Grabarek A, Złowocka-Perłowska E, Menkiszak J, Arason A, Barkardottir RB, Simard J, Laframboise R, Montagna M, Agata S, Alducci E, Peixoto A, Teixeira MR, Spurdle AB, Lee MH, Park SK, Kim SW, Friebel TM, Couch FJ, Lindor NM, Pankratz VS, Guidugli L, Wang X, Tischkowitz M, Foretova L, Vijai J, Offit K, Robson M, Rau-Murthy R, Kauff N, Fink-Retter A, Singer CF, Rappaport C, Gschwantler-Kaulich D, Pfeiler G, Tea MK, Berger A, Greene MH, Mai PL, Imyanitov EN, Toland AE, Senter L, Bojesen A, Pedersen IS, Skytte AB, Sunde L, Thomassen M, Moeller ST, Kruse TA, Jensen UB, Caligo MA, Aretini P, Teo SH, Selkirk CG, Hulick PJ, Andrulis I. JAMA 313 1347-1361 (2015)
  16. The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Yang H, Li Q, Fan J, Holloman WK, Pavletich NP. Nature 433 653-657 (2005)
  17. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W. Mol Cell Biol 23 3417-3426 (2003)
  18. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Wang X, Andreassen PR, D'Andrea AD. Mol Cell Biol 24 5850-5862 (2004)
  19. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V. Mol Cell 67 867-881.e7 (2017)
  20. Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Bochkareva E, Kaustov L, Ayed A, Yi GS, Lu Y, Pineda-Lucena A, Liao JC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A. Proc Natl Acad Sci U S A 102 15412-15417 (2005)
  21. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. EMBO J 22 4566-4576 (2003)
  22. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Houghtaling S, Timmers C, Noll M, Finegold MJ, Jones SN, Meyn MS, Grompe M. Genes Dev 17 2021-2035 (2003)
  23. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. Mol Cell 32 735-746 (2008)
  24. DNA binding and nucleotide flipping by the human DNA repair protein AGT. Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA. Nat Struct Mol Biol 11 714-720 (2004)
  25. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Esashi F, Galkin VE, Yu X, Egelman EH, West SC. Nat Struct Mol Biol 14 468-474 (2007)
  26. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. García-Rubio ML, Pérez-Calero C, Barroso SI, Tumini E, Herrera-Moyano E, Rosado IV, Aguilera A. PLoS Genet 11 e1005674 (2015)
  27. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC. Nat Struct Mol Biol 17 1263-1265 (2010)
  28. The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Carreira A, Hilario J, Amitani I, Baskin RJ, Shivji MK, Venkitaraman AR, Kowalczykowski SC. Cell 136 1032-1043 (2009)
  29. Cancer suppression by the chromosome custodians, BRCA1 and BRCA2. Venkitaraman AR. Science 343 1470-1475 (2014)
  30. Proteasome involvement in the repair of DNA double-strand breaks. Krogan NJ, Lam MH, Fillingham J, Keogh MC, Gebbia M, Li J, Datta N, Cagney G, Buratowski S, Emili A, Greenblatt JF. Mol Cell 16 1027-1034 (2004)
  31. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Davies OR, Pellegrini L. Nat Struct Mol Biol 14 475-483 (2007)
  32. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Tutt AN, Lord CJ, McCabe N, Farmer H, Turner N, Martin NM, Jackson SP, Smith GC, Ashworth A. Cold Spring Harb Symp Quant Biol 70 139-148 (2005)
  33. RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Martin JS, Winkelmann N, Petalcorin MI, McIlwraith MJ, Boulton SJ. Mol Cell Biol 25 3127-3139 (2005)
  34. Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions? Mark WY, Liao JC, Lu Y, Ayed A, Laister R, Szymczyna B, Chakrabartty A, Arrowsmith CH. J Mol Biol 345 275-287 (2005)
  35. Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1. Siaud N, Dray E, Gy I, Gérard E, Takvorian N, Doutriaux MP. EMBO J 23 1392-1401 (2004)
  36. BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Schoenfeld AR, Apgar S, Dolios G, Wang R, Aaronson SA. Mol Cell Biol 24 7444-7455 (2004)
  37. Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P. Mol Cell 59 176-187 (2015)
  38. Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Yamamoto K, Ishiai M, Matsushita N, Arakawa H, Lamerdin JE, Buerstedde JM, Tanimoto M, Harada M, Thompson LH, Takata M. Mol Cell Biol 23 5421-5430 (2003)
  39. Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. Kerr ID, Wadsworth RI, Cubeddu L, Blankenfeldt W, Naismith JH, White MF. EMBO J 22 2561-2570 (2003)
  40. Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. San Filippo J, Chi P, Sehorn MG, Etchin J, Krejci L, Sung P. J Biol Chem 281 11649-11657 (2006)
  41. Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms. Carreira A, Kowalczykowski SC. Proc Natl Acad Sci U S A 108 10448-10453 (2011)
  42. Functional assays for classification of BRCA2 variants of uncertain significance. Farrugia DJ, Agarwal MK, Pankratz VS, Deffenbaugh AM, Pruss D, Frye C, Wadum L, Johnson K, Mentlick J, Tavtigian SV, Goldgar DE, Couch FJ. Cancer Res 68 3523-3531 (2008)
  43. Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2. Kuznetsov SG, Liu P, Sharan SK. Nat Med 14 875-881 (2008)
  44. The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. Kojic M, Yang H, Kostrub CF, Pavletich NP, Holloman WK. Mol Cell 12 1043-1049 (2003)
  45. DSS1 is required for the stability of BRCA2. Li J, Zou C, Bai Y, Wazer DE, Band V, Gao Q. Oncogene 25 1186-1194 (2006)
  46. BRCA2 is required for neurogenesis and suppression of medulloblastoma. Frappart PO, Lee Y, Lamont J, McKinnon PJ. EMBO J 26 2732-2742 (2007)
  47. DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Youds JL, Barber LJ, Ward JD, Collis SJ, O'Neil NJ, Boulton SJ, Rose AM. Mol Cell Biol 28 1470-1479 (2008)
  48. DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. Gudmundsdottir K, Lord CJ, Witt E, Tutt AN, Ashworth A. EMBO Rep 5 989-993 (2004)
  49. Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Saeki H, Siaud N, Christ N, Wiegant WW, van Buul PP, Han M, Zdzienicka MZ, Stark JM, Jasin M. Proc Natl Acad Sci U S A 103 8768-8773 (2006)
  50. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W. J Biol Chem 284 23525-23531 (2009)
  51. Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. Lo T, Pellegrini L, Venkitaraman AR, Blundell TL. DNA Repair (Amst) 2 1015-1028 (2003)
  52. A classification model for BRCA2 DNA binding domain missense variants based on homology-directed repair activity. Guidugli L, Pankratz VS, Singh N, Thompson J, Erding CA, Engel C, Schmutzler R, Domchek S, Nathanson K, Radice P, Singer C, Tonin PN, Lindor NM, Goldgar DE, Couch FJ. Cancer Res 73 265-275 (2013)
  53. Assessment of functional effects of unclassified genetic variants. Couch FJ, Rasmussen LJ, Hofstra R, Monteiro AN, Greenblatt MS, de Wind N, IARC Unclassified Genetic Variants Working Group. Hum Mutat 29 1314-1326 (2008)
  54. Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery. Faza MB, Kemmler S, Jimeno S, González-Aguilera C, Aguilera A, Hurt E, Panse VG. J Cell Biol 184 833-846 (2009)
  55. Mechanism of RecO recruitment to DNA by single-stranded DNA binding protein. Ryzhikov M, Koroleva O, Postnov D, Tran A, Korolev S. Nucleic Acids Res 39 6305-6314 (2011)
  56. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR. Nat Struct Mol Biol 20 1191-1198 (2013)
  57. Cancer variation associated with the position of the mutation in the BRCA2 gene. Lubinski J, Phelan CM, Ghadirian P, Lynch HT, Garber J, Weber B, Tung N, Horsman D, Isaacs C, Monteiro AN, Sun P, Narod SA. Fam Cancer 3 1-10 (2004)
  58. PALB2 regulates recombinational repair through chromatin association and oligomerization. Sy SM, Huen MS, Zhu Y, Chen J. J Biol Chem 284 18302-18310 (2009)
  59. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff JA, Shen Z. Mol Cell Biol 25 1949-1957 (2005)
  60. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH. Structure 19 418-429 (2011)
  61. A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Shivji MK, Davies OR, Savill JM, Bates DL, Pellegrini L, Venkitaraman AR. Nucleic Acids Res 34 4000-4011 (2006)
  62. Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses. Wang S, Durrant WE, Song J, Spivey NW, Dong X. Proc Natl Acad Sci U S A 107 22716-22721 (2010)
  63. BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis. Mondal G, Rowley M, Guidugli L, Wu J, Pankratz VS, Couch FJ. Dev Cell 23 137-152 (2012)
  64. Characterization of Arabidopsis thaliana ortholog of the human breast cancer susceptibility gene 1: AtBRCA1, strongly induced by gamma rays. Lafarge S, Montané MH. Nucleic Acids Res 31 1148-1155 (2003)
  65. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H. Cell Rep 4 327-339 (2013)
  66. Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Shahid T, Soroka J, Kong E, Malivert L, McIlwraith MJ, Pape T, West SC, Zhang X. Nat Struct Mol Biol 21 962-968 (2014)
  67. Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Hatanaka A, Yamazoe M, Sale JE, Takata M, Yamamoto K, Kitao H, Sonoda E, Kikuchi K, Yonetani Y, Takeda S. Mol Cell Biol 25 1124-1134 (2005)
  68. Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination. Hartley CL, McCulloch R. Mol Microbiol 68 1237-1251 (2008)
  69. An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Zhu W, Dutta A. Mol Cell Biol 26 4601-4611 (2006)
  70. Description and analysis of genetic variants in French hereditary breast and ovarian cancer families recorded in the UMD-BRCA1/BRCA2 databases. Caputo S, Benboudjema L, Sinilnikova O, Rouleau E, Béroud C, Lidereau R, French BRCA GGC Consortium. Nucleic Acids Res 40 D992-1002 (2012)
  71. Dss1 is a 26S proteasome ubiquitin receptor. Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C. Mol Cell 56 453-461 (2014)
  72. Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes. Kumaran S, Kozlov AG, Lohman TM. Biochemistry 45 11958-11973 (2006)
  73. Interaction between Arabidopsis Brca2 and its partners Rad51, Dmc1, and Dss1. Dray E, Siaud N, Dubois E, Doutriaux MP. Plant Physiol 140 1059-1069 (2006)
  74. Binding and activation of DNA topoisomerase III by the Rmi1 subunit. Chen CF, Brill SJ. J Biol Chem 282 28971-28979 (2007)
  75. Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing. Bodian DL, McCutcheon JN, Kothiyal P, Huddleston KC, Iyer RK, Vockley JG, Niederhuber JE. PLoS One 9 e94554 (2014)
  76. The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis. Tomko RJ, Hochstrasser M. Mol Cell 53 433-443 (2014)
  77. Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma. Akbari MR, Malekzadeh R, Nasrollahzadeh D, Amanian D, Islami F, Li S, Zandvakili I, Shakeri R, Sotoudeh M, Aghcheli K, Salahi R, Pourshams A, Semnani S, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Oncogene 27 1290-1296 (2008)
  78. Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. Rodríguez-Marí A, Wilson C, Titus TA, Cañestro C, BreMiller RA, Yan YL, Nanda I, Johnston A, Kanki JP, Gray EM, He X, Spitsbergen J, Schindler D, Postlethwait JH. PLoS Genet 7 e1001357 (2011)
  79. The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Shivji MK, Mukund SR, Rajendra E, Chen S, Short JM, Savill J, Klenerman D, Venkitaraman AR. Proc Natl Acad Sci U S A 106 13254-13259 (2009)
  80. A novel role of the chromokinesin Kif4A in DNA damage response. Wu G, Zhou L, Khidr L, Guo XE, Kim W, Lee YM, Krasieva T, Chen PL. Cell Cycle 7 2013-2020 (2008)
  81. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. Petalcorin MI, Sandall J, Wigley DB, Boulton SJ. J Mol Biol 361 231-242 (2006)
  82. DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression. Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L. Proc Natl Acad Sci U S A 113 E4311-9 (2016)
  83. Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks. Rees HA, Yeh WH, Liu DR. Nat Commun 10 2212 (2019)
  84. Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis. Kojic M, Zhou Q, Lisby M, Holloman WK. Mol Cell Biol 25 2547-2557 (2005)
  85. The HIN domain of IFI-200 proteins consists of two OB folds. Albrecht M, Choubey D, Lengauer T. Biochem Biophys Res Commun 327 679-687 (2005)
  86. A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. Garncarz W, Tariq A, Handl C, Pusch O, Jantsch MF. RNA Biol 10 192-204 (2013)
  87. Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans. Leiros I, Timmins J, Hall DR, McSweeney S. EMBO J 24 906-918 (2005)
  88. Improved survival in BRCA2 carriers with ovarian cancer. Pal T, Permuth-Wey J, Kapoor R, Cantor A, Sutphen R. Fam Cancer 6 113-119 (2007)
  89. The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair. Yue J, Wang Q, Lu H, Brenneman M, Fan F, Shen Z. Cancer Res 69 7978-7985 (2009)
  90. Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. van Veelen LR, Essers J, van de Rakt MW, Odijk H, Pastink A, Zdzienicka MZ, Paulusma CC, Kanaar R. Mutat Res 574 34-49 (2005)
  91. Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B, Jasin M. PLoS Genet 7 e1002409 (2011)
  92. Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, Sharan SK. Hum Mol Genet 21 3993-4006 (2012)
  93. Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52. Seong C, Sehorn MG, Plate I, Shi I, Song B, Chi P, Mortensen U, Sung P, Krejci L. J Biol Chem 283 12166-12174 (2008)
  94. Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress. Wray J, Liu J, Nickoloff JA, Shen Z. Cancer Res 68 2699-2707 (2008)
  95. Structure-function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation. Quevillon-Cheruel S, Campo N, Mirouze N, Mortier-Barrière I, Brooks MA, Boudes M, Durand D, Soulet AL, Lisboa J, Noirot P, Martin B, van Tilbeurgh H, Noirot-Gros MF, Claverys JP, Polard P. Proc Natl Acad Sci U S A 109 E2466-75 (2012)
  96. The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Besmer E, Market E, Papavasiliou FN. Mol Cell Biol 26 4378-4385 (2006)
  97. A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Biswas K, Das R, Alter BP, Kuznetsov SG, Stauffer S, North SL, Burkett S, Brody LC, Meyer S, Byrd RA, Sharan SK. Blood 118 2430-2442 (2011)
  98. Does nonsense-mediated mRNA decay explain the ovarian cancer cluster region of the BRCA2 gene? Ware MD, DeSilva D, Sinilnikova OM, Stoppa-Lyonnet D, Tavtigian SV, Mazoyer S. Oncogene 25 323-328 (2006)
  99. The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response. Zhang F, Chen Y, Li M, Yu X. Proc Natl Acad Sci U S A 111 7278-7283 (2014)
  100. BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer. Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L, Martin C, Calléja FMGR, Meeks H, Hallberg E, Hinton J, Lilyquist J, Hu C, Aalfs CM, Aittomäki K, Andrulis I, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV, Bojesen SE, Bolla MK, Borresen-Dale AL, Brauch H, Brennan P, Brenner H, Broeks A, Brouwers B, Brüning T, Burwinkel B, Chang-Claude J, Chenevix-Trench G, Cheng CY, Choi JY, Collée JM, Cox A, Cross SS, Czene K, Darabi H, Dennis J, Dörk T, Dos-Santos-Silva I, Dunning AM, Fasching PA, Figueroa J, Flyger H, García-Closas M, Giles GG, Glendon G, Guénel P, Haiman CA, Hall P, Hamann U, Hartman M, Hogervorst FB, Hollestelle A, Hopper JL, Ito H, Jakubowska A, Kang D, Kosma VM, Kristensen V, Lai KN, Lambrechts D, Marchand LL, Li J, Lindblom A, Lophatananon A, Lubinski J, Machackova E, Mannermaa A, Margolin S, Marme F, Matsuo K, Miao H, Michailidou K, Milne RL, Muir K, Neuhausen SL, Nevanlinna H, Olson JE, Olswold C, Oosterwijk JJC, Osorio A, Peterlongo P, Peto J, Pharoah PDP, Pylkäs K, Radice P, Rashid MU, Rhenius V, Rudolph A, Sangrajrang S, Sawyer EJ, Schmidt MK, Schoemaker MJ, Seynaeve C, Shah M, Shen CY, Shrubsole M, Shu XO, Slager S, Southey MC, Stram DO, Swerdlow A, Teo SH, Tomlinson I, Torres D, Truong T, van Asperen CJ, van der Kolk LE, Wang Q, Winqvist R, Wu AH, Yu JC, Zheng W, Zheng Y, Leary J, Walker L, Foretova L, Fostira F, Claes KBM, Varesco L, Moghadasi S, Easton DF, Spurdle A, Devilee P, Vrieling H, Monteiro ANA, Goldgar DE, Carreira A, Vreeswijk MPG, Couch FJ, for kConFab/AOCS Investigators, for NBCS Collaborators. Cancer Res 77 2789-2799 (2017)
  101. Comparative in vitro and in silico analyses of variants in splicing regions of BRCA1 and BRCA2 genes and characterization of novel pathogenic mutations. Colombo M, De Vecchi G, Caleca L, Foglia C, Ripamonti CB, Ficarazzi F, Barile M, Varesco L, Peissel B, Manoukian S, Radice P. PLoS One 8 e57173 (2013)
  102. Homologous recombination is required for AAV-mediated gene targeting. Vasileva A, Linden RM, Jessberger R. Nucleic Acids Res 34 3345-3360 (2006)
  103. Physical and functional interaction of the archaeal single-stranded DNA-binding protein SSB with RNA polymerase. Richard DJ, Bell SD, White MF. Nucleic Acids Res 32 1065-1074 (2004)
  104. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair. Hilmi K, Jangal M, Marques M, Zhao T, Saad A, Zhang C, Luo VM, Syme A, Rejon C, Yu Z, Krum A, Fabian MR, Richard S, Alaoui-Jamali M, Orthwein A, McCaffrey L, Witcher M. Sci Adv 3 e1601898 (2017)
  105. Chemosensitivity and radiosensitivity profiles of four new human epithelial ovarian cancer cell lines exhibiting genetic alterations in BRCA2, TGFbeta-RII, KRAS2, TP53 and/or CDNK2A. Samouëlian V, Maugard CM, Jolicoeur M, Bertrand R, Arcand SL, Tonin PN, Provencher DM, Mes-Masson AM. Cancer Chemother Pharmacol 54 497-504 (2004)
  106. Nucleotide shuffling and ssDNA recognition in Oxytricha nova telomere end-binding protein complexes. Theobald DL, Schultz SC. EMBO J 22 4314-4324 (2003)
  107. Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast. Thakurta AG, Gopal G, Yoon JH, Kozak L, Dhar R. EMBO J 24 2512-2523 (2005)
  108. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Lu H, Yue J, Meng X, Nickoloff JA, Shen Z. Nucleic Acids Res 35 7160-7170 (2007)
  109. BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana. Seeliger K, Dukowic-Schulze S, Wurz-Wildersinn R, Pacher M, Puchta H. New Phytol 193 364-375 (2012)
  110. The proteasome is involved in determining differential utilization of double-strand break repair pathways. Gudmundsdottir K, Lord CJ, Ashworth A. Oncogene 26 7601-7606 (2007)
  111. Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response. Zhang F, Shi J, Bian C, Yu X. Cell Rep 13 678-689 (2015)
  112. BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Tian XX, Rai D, Li J, Zou C, Bai Y, Wazer D, Band V, Gao Q. Cancer Res 65 4747-4753 (2005)
  113. POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis. Llorens-Agost M, Ensminger M, Le HP, Gawai A, Liu J, Cruz-García A, Bhetawal S, Wood RD, Heyer WD, Löbrich M. Nat Cell Biol 23 1095-1104 (2021)
  114. Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair. Zhou Q, Kojic M, Cao Z, Lisby M, Mazloum NA, Holloman WK. Mol Cell Biol 27 2512-2526 (2007)
  115. Presynaptic filament dynamics in homologous recombination and DNA repair. Liu J, Ehmsen KT, Heyer WD, Morrical SW. Crit Rev Biochem Mol Biol 46 240-270 (2011)
  116. DNA binding, annealing, and strand exchange activities of Brh2 protein from Ustilago maydis. Mazloum N, Zhou Q, Holloman WK. Biochemistry 46 7163-7173 (2007)
  117. Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas. Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod SA, Koeffler HP, Karlan BY. Clin Cancer Res 14 7645-7651 (2008)
  118. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. Rozen S, Füzesi-Levi MG, Ben-Nissan G, Mizrachi L, Gabashvili A, Levin Y, Ben-Dor S, Eisenstein M, Sharon M. Cell Rep 13 585-598 (2015)
  119. Deep trefoil knot implicated in RNA binding found in an archaebacterial protein. Zarembinski TI, Kim Y, Peterson K, Christendat D, Dharamsi A, Arrowsmith CH, Edwards AM, Joachimiak A. Proteins 50 177-183 (2003)
  120. Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity. Chatterjee G, Jimenez-Sainz J, Presti T, Nguyen T, Jensen RB. Nucleic Acids Res 44 5256-5270 (2016)
  121. Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links. Rickman KA, Noonan RJ, Lach FP, Sridhar S, Wang AT, Abhyankar A, Huang A, Kelly M, Auerbach AD, Smogorzewska A. Genes Dev 34 832-846 (2020)
  122. Structural D/E-rich repeats play multiple roles especially in gene regulation through DNA/RNA mimicry. Chou CC, Wang AH. Mol Biosyst 11 2144-2151 (2015)
  123. BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer? Powell SN, Willers H, Xia F. Mol Cell 10 1262-1263 (2002)
  124. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S. J Biol Chem 287 6604-6614 (2012)
  125. Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. Rajagopalan S, Andreeva A, Rutherford TJ, Fersht AR. Proc Natl Acad Sci U S A 107 8587-8592 (2010)
  126. Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC. Bazzi A, Zargarian L, Chaminade F, Boudier C, De Rocquigny H, René B, Mély Y, Fossé P, Mauffret O. Nucleic Acids Res 39 3903-3916 (2011)
  127. Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1. Wei C, Price CM. Mol Cell Biol 24 2091-2102 (2004)
  128. Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer. Hu N, Wang C, Han XY, He LJ, Tang ZZ, Giffen C, Emmert-Buck MR, Goldstein AM, Taylor PR. Oncogene 23 852-858 (2004)
  129. Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW. J Mol Biol 383 693-712 (2008)
  130. Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. Genois MM, Mukherjee A, Ubeda JM, Buisson R, Paquet E, Roy G, Plourde M, Coulombe Y, Ouellette M, Masson JY. Nucleic Acids Res 40 6570-6584 (2012)
  131. The process of displacing the single-stranded DNA-binding protein from single-stranded DNA by RecO and RecR proteins. Inoue J, Honda M, Ikawa S, Shibata T, Mikawa T. Nucleic Acids Res 36 94-109 (2008)
  132. Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair. Sánchez H, Paul MW, Grosbart M, van Rossum-Fikkert SE, Lebbink JHG, Kanaar R, Houtsmuller AB, Wyman C. Nucleic Acids Res 45 4507-4518 (2017)
  133. C. elegans dss-1 is functionally conserved and required for oogenesis and larval growth. Pispa J, Palmén S, Holmberg CI, Jäntti J. BMC Dev Biol 8 51 (2008)
  134. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Jossé L, Harley ME, Pires IM, Hughes DA. Biochem J 393 303-309 (2006)
  135. Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth. Liu J, Kruswick A, Dang H, Tran AD, Kwon SM, Wang XW, Oberdoerffer P. Nat Commun 8 137 (2017)
  136. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, Anta JJ, de los Rios M, Carnesolta D, del Olivera MC, Vansam SS, Royer R, Akbari MR, Donenberg T, Narod SA. Fam Cancer 7 275-279 (2008)
  137. Letter Designed proteins to modulate cellular networks. Cortajarena AL, Liu TY, Hochstrasser M, Regan L. ACS Chem Biol 5 545-552 (2010)
  138. Localization of the regulatory particle subunit Sem1 in the 26S proteasome. Bohn S, Sakata E, Beck F, Pathare GR, Schnitger J, Nágy I, Baumeister W, Förster F. Biochem Biophys Res Commun 435 250-254 (2013)
  139. Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1. Pohl TJ, Nickoloff JA. Mol Cell Biol 28 897-906 (2008)
  140. Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. Wu M, Park YJ, Pardon E, Turley S, Hayhurst A, Deng J, Steyaert J, Hol WG. J Struct Biol 174 124-136 (2011)
  141. A second DNA binding site in human BRCA2 promotes homologous recombination. von Nicolai C, Ehlén Å, Martin C, Zhang X, Carreira A. Nat Commun 7 12813 (2016)
  142. Homologs of breast cancer genes in plants. Trapp O, Seeliger K, Puchta H. Front Plant Sci 2 19 (2011)
  143. Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Eastberg JH, Pelletier J, Stoddard BL. Nucleic Acids Res 32 653-660 (2004)
  144. Functional analysis of Drosophila melanogaster BRCA2 in DNA repair. Brough R, Wei D, Leulier S, Lord CJ, Rong YS, Ashworth A. DNA Repair (Amst) 7 10-19 (2008)
  145. Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex. Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T. Structure 20 440-449 (2012)
  146. The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. Zhoucun A, Zhang S, Yang Y, Ma Y, Zhang W, Lin L. Eur J Obstet Gynecol Reprod Biol 124 61-64 (2006)
  147. The human Rad51 K133A mutant is functional for DNA double-strand break repair in human cells. Forget AL, Loftus MS, McGrew DA, Bennett BT, Knight KL. Biochemistry 46 3566-3575 (2007)
  148. Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients. Eoh KJ, Park HS, Park JS, Lee ST, Han J, Lee JY, Kim SW, Kim S, Kim YT, Nam EJ. Cancer Res Treat 49 408-415 (2017)
  149. GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S. Nucleic Acids Res 38 5059-5074 (2010)
  150. Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. Su H, Cheng Z, Huang J, Lin J, Copenhaver GP, Ma H, Wang Y. PLoS Genet 13 e1006827 (2017)
  151. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. Stoepker C, Faramarz A, Rooimans MA, van Mil SE, Balk JA, Velleuer E, Ameziane N, Te Riele H, de Winter JP. DNA Repair (Amst) 26 54-64 (2015)
  152. The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain. Lewis KA, Pfaff DA, Earley JN, Altschuler SE, Wuttke DS. Nucleic Acids Res 42 475-484 (2014)
  153. Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51. Tal A, Arbel-Goren R, Stavans J. J Mol Biol 393 1007-1012 (2009)
  154. Comment Cancer: catalyst of a catalyst. Kowalczykowski SC. Nature 433 591-592 (2005)
  155. Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis. Kojic M, Zhou Q, Lisby M, Holloman WK. Mol Cell Biol 26 678-688 (2006)
  156. Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Inturi S, Tewari-Singh N, Agarwal C, White CW, Agarwal R. Mutat Res 763-764 53-63 (2014)
  157. Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population. da Costa E Silva Carvalho S, Cury NM, Brotto DB, de Araujo LF, Rosa RCA, Texeira LA, Plaça JR, Marques AA, Peronni KC, Ruy PC, Molfetta GA, Moriguti JC, Carraro DM, Palmero EI, Ashton-Prolla P, de Faria Ferraz VE, Silva WA. BMC Med Genomics 13 21 (2020)
  158. Molecular mechanism of DNA association with single-stranded DNA binding protein. Maffeo C, Aksimentiev A. Nucleic Acids Res 45 12125-12139 (2017)
  159. NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Kang HS, Beak JY, Kim YS, Petrovich RM, Collins JB, Grissom SF, Jetten AM. Biochem J 397 89-99 (2006)
  160. Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families. Novaković S, Milatović M, Cerkovnik P, Stegel V, Krajc M, Hočevar M, Zgajnar J, Vakselj A. Int J Oncol 41 1619-1627 (2012)
  161. Role of the N-terminal domain of the human DMC1 protein in octamer formation and DNA binding. Kinebuchi T, Kagawa W, Kurumizaka H, Yokoyama S. J Biol Chem 280 28382-28387 (2005)
  162. Biochemistry of eukaryotic homologous recombination. Heyer WD. Top Curr Genet 17 95-133 (2007)
  163. D-loop formation by Brh2 protein of Ustilago maydis. Mazloum N, Zhou Q, Holloman WK. Proc Natl Acad Sci U S A 105 524-529 (2008)
  164. DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA. Zhou Q, Kojic M, Holloman WK. J Biol Chem 284 8265-8273 (2009)
  165. Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites. Haas KT, Lee M, Esposito A, Venkitaraman AR. Nucleic Acids Res 46 2398-2416 (2018)
  166. DNA-binding properties of T4 UvsY recombination mediator protein: polynucleotide wrapping promotes high-affinity binding to single-stranded DNA. Xu H, Beernink HT, Morrical SW. Nucleic Acids Res 38 4821-4833 (2010)
  167. Dysfunctional telomeres in human BRCA2 mutated breast tumors and cell lines. Bodvarsdottir SK, Steinarsdottir M, Bjarnason H, Eyfjord JE. Mutat Res 729 90-99 (2012)
  168. Effect of the expression of BRCA2 on spontaneous homologous recombination and DNA damage-induced nuclear foci in Saccharomyces cerevisiae. Spugnesi L, Balia C, Collavoli A, Falaschi E, Quercioli V, Caligo MA, Galli A. Mutagenesis 28 187-195 (2013)
  169. Sequence, structure and evolutionary analysis of cold shock domain proteins, a member of OB fold family. Amir M, Kumar V, Dohare R, Islam A, Ahmad F, Hassan MI. J Evol Biol 31 1903-1917 (2018)
  170. Targeting the OB-Folds of Replication Protein A with Small Molecules. Anciano Granadillo VJ, Earley JN, Shuck SC, Georgiadis MM, Fitch RW, Turchi JJ. J Nucleic Acids 2010 304035 (2010)
  171. Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates. Ehmsen KT, Heyer WD. Genome Dyn Stab 3 91 (2008)
  172. Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer. Barber LJ, Rosa Rosa JM, Kozarewa I, Fenwick K, Assiotis I, Mitsopoulos C, Sims D, Hakas J, Zvelebil M, Lord CJ, Ashworth A. PLoS One 6 e21639 (2011)
  173. DSS1 and ssDNA regulate oligomerization of BRCA2. Le HP, Ma X, Vaquero J, Brinkmeyer M, Guo F, Heyer WD, Liu J. Nucleic Acids Res 48 7818-7833 (2020)
  174. Dss1 regulates interaction of Brh2 with DNA. Zhou Q, Mazloum N, Mao N, Kojic M, Holloman WK. Biochemistry 48 11929-11938 (2009)
  175. High-Intensity Exercise Decreases IP6K1 Muscle Content and Improves Insulin Sensitivity (SI2*) in Glucose-Intolerant Individuals. Naufahu J, Elliott B, Markiv A, Dunning-Foreman P, McGrady M, Howard D, Watt P, Mackenzie RWA. J Clin Endocrinol Metab 103 1479-1490 (2018)
  176. Identification of the most common BRCA alterations through analysis of germline mutation databases: Is droplet digital PCR an additional strategy for the assessment of such alterations in breast and ovarian cancer families? Lavoro A, Scalisi A, Candido S, Zanghì GN, Rizzo R, Gattuso G, Caruso G, Libra M, Falzone L. Int J Oncol 60 58 (2022)
  177. Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL. Takaku M, Machida S, Hosoya N, Nakayama S, Takizawa Y, Sakane I, Shibata T, Miyagawa K, Kurumizaka H. J Biol Chem 284 14326-14336 (2009)
  178. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA. Structure 18 537-547 (2010)
  179. Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer. Caputo SM, Léone M, Damiola F, Ehlen A, Carreira A, Gaidrat P, Martins A, Brandão RD, Peixoto A, Vega A, Houdayer C, Delnatte C, Bronner M, Muller D, Castera L, Guillaud-Bataille M, Søkilde I, Uhrhammer N, Demontety S, Tubeuf H, Castelain G, French COVAR group collaborators, Jensen UB, Petitalot A, Krieger S, Lefol C, Moncoutier V, Boutry-Kryza N, Nielsen HR, Sinilnikova O, Stoppa-Lyonnet D, Spurdle AB, Teixeira MR, Coulet F, Thomassen M, Rouleau E. Oncotarget 9 17334-17348 (2018)
  180. Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Huang C, Li G, Wu J, Liang J, Wang X. Genome Biol 22 80 (2021)
  181. News Mediating repair. Sung P. Nat Struct Mol Biol 12 213-214 (2005)
  182. Mutational analysis of Brh2 reveals requirements for compensating mediator functions. Kojic M, Zhou Q, Fan J, Holloman WK. Mol Microbiol 79 180-191 (2011)
  183. Reduced canine BRCA2 expression levels in mammary gland tumors. Yoshikawa Y, Morimatsu M, Ochiai K, Ishiguro-Oonuma T, Wada S, Orino K, Watanabe K. BMC Vet Res 11 159 (2015)
  184. The BRCA2 c.9004G>A (E2002K) [corrected] variant is likely pathogenic and recurs in breast and/or ovarian cancer families of French Canadian descent. Cote S, Arcand SL, Royer R, Nolet S, Mes-Masson AM, Ghadirian P, Foulkes WD, Tischkowitz M, Narod SA, Provencher D, Tonin PN. Breast Cancer Res Treat 131 333-340 (2012)
  185. 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. Wei SJ, Trempus CS, Ali RC, Hansen LA, Tennant RW. J Biol Chem 279 5993-6004 (2004)
  186. A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays. Biswas K, Lipton GB, Stauffer S, Sullivan T, Cleveland L, Southon E, Reid S, Magidson V, Iversen ES, Sharan SK. NPJ Genom Med 5 52 (2020)
  187. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins. Shinn MK, Kozlov AG, Lohman TM. Nucleic Acids Res 49 1987-2004 (2021)
  188. High levels of wild-type BRCA2 suppress homologous recombination. Magwood AC, Mundia MM, Baker MD. J Mol Biol 421 38-53 (2012)
  189. Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis. Mao N, Zhou Q, Kojic M, Pérez-Martín J, Holloman WK. DNA Repair (Amst) 6 1651-1660 (2007)
  190. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, Rebula CA, Tatham MH, Hendus-Altenburger R, Jourdain I, Hay RT, Kragelund BB, Hartmann-Petersen R. Cell Rep 25 862-870 (2018)
  191. Functional inactivation of the conserved Sem1p in yeast by intrabodies. Reinman M, Jäntti J, Alfthan K, Keränen S, Söderlund H, Takkinen K. Yeast 20 1071-1084 (2003)
  192. Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations. Ahlborn LB, Steffensen AY, Jønson L, Djursby M, Nielsen FC, Gerdes AM, Hansen TV. Fam Cancer 14 129-133 (2015)
  193. NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection. Shibata W, Hirata Y, Yoshida H, Otsuka M, Hoshida Y, Ogura K, Maeda S, Ohmae T, Yanai A, Mitsuno Y, Seki N, Kawabe T, Omata M. World J Gastroenterol 11 6134-6143 (2005)
  194. RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms. Ryzhikov M, Gupta R, Glickman M, Korolev S. J Biol Chem 289 28846-28855 (2014)
  195. Sensitive fluorescence assay of anthrax protective antigen with two new DNA aptamers and their binding properties. Oh BN, Lee S, Park HY, Baeg JO, Yoon MY, Kim J. Analyst 136 3384-3388 (2011)
  196. Research Support, Non-U.S. Gov't BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51. Carreira A, Kowalczykowski SC. Cell Cycle 8 3445-3447 (2009)
  197. Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA. Fitzgerald ME, Vela A, Pyle AM. Nucleic Acids Res 42 3919-3930 (2014)
  198. On BLM helicase in recombination-mediated telomere maintenance. Rezazadeh S. Mol Biol Rep 40 3049-3064 (2013)
  199. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. Zhang Y, Chang FM, Huang J, Junco JJ, Maffi SK, Pridgen HI, Catano G, Dang H, Ding X, Yang F, Kim DJ, Slaga TJ, He R, Wei SJ. Protein Cell 5 124-140 (2014)
  200. Effects of ssDNA sequences on non-sequence-specific protein binding. Mou TC, Shen M, Abdalla S, Delamora D, Bochkareva E, Bochkarev A, Gray DM. Chirality 18 370-382 (2006)
  201. GEMO, a National Resource to Study Genetic Modifiers of Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Pathogenic Variant Carriers. Lesueur F, Mebirouk N, Jiao Y, Barjhoux L, Belotti M, Laurent M, Léone M, Houdayer C, Bressac-de Paillerets B, Vaur D, Sobol H, Noguès C, Longy M, Mortemousque I, Fert-Ferrer S, Mouret-Fourme E, Pujol P, Venat-Bouvet L, Bignon YJ, Leroux D, Coupier I, Berthet P, Mari V, Delnatte C, Gesta P, Collonge-Rame MA, Giraud S, Bonadona V, Baurand A, Faivre L, Buecher B, Lasset C, Gauthier-Villars M, Damiola F, Mazoyer S, Caputo SM, Andrieu N, Stoppa-Lyonnet D, GEMO Study Collaborators. Front Oncol 8 490 (2018)
  202. BRCA1 and BRCA2 germline variants in breast cancer patients from the Republic of Macedonia. Jakimovska M, Maleva Kostovska I, Popovska-Jankovic K, Kubelka-Sabit K, Karadjozov M, Stojanovska L, Arsovski A, Smichkoska S, Lazarova E, Jakimovska Dimitrovska M, Plaseska-Karanfilska D. Breast Cancer Res Treat 168 745-753 (2018)
  203. Characterization of the Chimeric PriB-SSBc Protein. Lin ES, Huang YH, Huang CY. Int J Mol Sci 22 10854 (2021)
  204. Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients. Ronowicz A, Janaszak-Jasiecka A, Skokowski J, Madanecki P, Bartoszewski R, Bałut M, Seroczyńska B, Kochan K, Bogdan A, Butkus M, Pęksa R, Ratajska M, Kuźniacka A, Wasąg B, Gucwa M, Krzyżanowski M, Jaśkiewicz J, Jankowski Z, Forsberg L, Ochocka JR, Limon J, Crowley MR, Buckley PG, Messiaen L, Dumanski JP, Piotrowski A. Hum Mutat 36 1088-1099 (2015)
  205. Contribution of germ line BRCA2 sequence alterations to risk of familial esophageal cancer in a high-risk area of India. Kaushal M, Chattopadhyay I, Phukan R, Purkayastha J, Mahanta J, Kapur S, Saxena S. Dis Esophagus 23 71-75 (2010)
  206. Distribution and cluster analysis of predicted intrinsically disordered protein Pfam domains. Williams RW, Xue B, Uversky VN, Dunker AK. Intrinsically Disord Proteins 1 e25724 (2013)
  207. Globally Rare BRCA2 Variants With Founder Haplotypes in the South African Population: Implications for Point-of-Care Testing Based on a Single-Institution BRCA1/2 Next-Generation Sequencing Study. Oosthuizen J, Kotze MJ, Van Der Merwe N, Myburgh EJ, Bester P, van der Merwe NC. Front Oncol 10 619469 (2020)
  208. In silico analysis for determining the deleterious nonsynonymous single nucleotide polymorphisms of BRCA genes. Yadegari F, Majidzadeh K. Mol Biol Res Commun 8 141-150 (2019)
  209. Congress Recombination mechanisms; fortieth anniversary meeting of the Holliday model. Heyer WD, Kanaar R. Mol Cell 16 1-9 (2004)
  210. Taxonomic distribution, repeats, and functions of the S1 domain-containing proteins as members of the OB-fold family. Deryusheva EI, Machulin AV, Selivanova OM, Galzitskaya OV. Proteins 85 602-613 (2017)
  211. A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair. Esposito MV, Minopoli G, Esposito L, D'Argenio V, Di Maggio F, Sasso E, D'Aiuto M, Zambrano N, Salvatore F. Cancers (Basel) 11 E1454 (2019)
  212. BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL-induced DNA damage and endothelial apoptosis. Singh S, Nguyen H, Michels D, Bazinet H, Matkar PN, Liu Z, Esene L, Adam M, Bugyei-Twum A, Mebrahtu E, Joseph J, Ehsan M, Chen HH, Qadura M, Singh KK. Physiol Rep 8 e14481 (2020)
  213. Brh2 domain function distinguished by differential cellular responses to DNA damage and replication stress. Kojic M, Holloman WK. Mol Microbiol 83 351-361 (2012)
  214. Clinical and molecular characterization of the BRCA2 p.Asn3124Ile variant reveals substantial evidence for pathogenic significance. Surowy HM, Sutter C, Mittnacht M, Klaes R, Schaefer D, Evers C, Burgemeister AL, Goehringer C, Dikow N, Heil J, Golatta M, Schott S, Schneeweiss A, Bugert P, Sohn C, Bartram CR, Burwinkel B. Breast Cancer Res Treat 145 451-460 (2014)
  215. Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction. Sidhu A, Grosbart M, Sánchez H, Verhagen B, van der Zon NLL, Ristić D, van Rossum-Fikkert SE, Wyman C. Nucleic Acids Res 48 9649-9659 (2020)
  216. Dss1 release activates DNA binding potential in Brh2. Zhou Q, Kojic M, Holloman WK. Biochemistry 51 9137-9146 (2012)
  217. Identification of Rad51 regulation by BRCA2 using Caenorhabditis elegans BRCA2 and bimolecular fluorescence complementation analysis. Min J, Park PG, Ko E, Choi E, Lee H. Biochem Biophys Res Commun 362 958-964 (2007)
  218. Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei. Hall M, Misra S, Chaudhuri M, Chaudhuri G. Microb Pathog 50 252-262 (2011)
  219. Roles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA Annealing. Khade NV, Sugiyama T. PLoS One 11 e0158436 (2016)
  220. Serbian high-risk families: extensive results on BRCA mutation spectra and frequency. Dobričić J, Krivokuća A, Brotto K, Mališić E, Radulović S, Branković-Magić M. J Hum Genet 58 501-507 (2013)
  221. The 26S proteasome drives trinucleotide repeat expansions. Concannon C, Lahue RS. Nucleic Acids Res 41 6098-6108 (2013)
  222. The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function. Ruidiaz SF, Dreier JE, Hartmann-Petersen R, Kragelund BB. Protein Sci 30 2069-2082 (2021)
  223. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Tamilzhalagan S, Muthuswami M, Periasamy J, Lee MH, Rha SY, Tan P, Ganesan K. Cell Signal 27 1075-1086 (2015)
  224. Astrocytoma in a breast cancer lineage: part of the BRCA2 phenotype? Wilson BT, Douglas SF, Polvikoski T. J Clin Oncol 28 e596-8 (2010)
  225. BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity. Sioftanos G, Ismail A, Föhse L, Shanley S, Worku M, Short SC. Int J Radiat Biol 86 1095-1105 (2010)
  226. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Nucleic Acids Res 44 10467-10479 (2016)
  227. Functional Validation of Rare Human Genetic Variants Involved in Homologous Recombination Using Saccharomyces cerevisiae. Lee MS, Yu M, Kim KY, Park GH, Kwack K, Kim KP. PLoS One 10 e0124152 (2015)
  228. Novel mutations in actionable breast cancer genes by targeted sequencing in an ethnically homogenous cohort. Akter H, Sultana N, Martuza N, Siddiqua A, Dity NJ, Rahaman MA, Samara B, Sayeed A, Basiruzzaman M, Rahman MM, Rashidul Hoq M, Amin MR, Baqui MA, Woodbury-Smith M, Uddin KMF, Islam SS, Awwal R, Berdiev BK, Uddin M. BMC Med Genet 20 150 (2019)
  229. Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations. Holt JT, Toole WP, Patel VR, Hwang H, Brown ET. Cancer Genet Cytogenet 186 85-94 (2008)
  230. Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks. Selvanathan SP, Thakurta AG, Dhakshnamoorthy J, Zhou M, Veenstra TD, Dhar R. J Biol Chem 285 14122-14133 (2010)
  231. Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. Heijink AM, Stok C, Porubsky D, Manolika EM, de Kanter JK, Kok YP, Everts M, de Boer HR, Audrey A, Bakker FJ, Wierenga E, Tijsterman M, Guryev V, Spierings DCJ, Knipscheer P, van Boxtel R, Ray Chaudhuri A, Lansdorp PM, van Vugt MATM. Nat Commun 13 6722 (2022)
  232. The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia. Stanley EC, Azzinaro PA, Vierra DA, Howlett NG, Irvine SQ. Evol Bioinform Online 12 133-148 (2016)
  233. A context-dependent and disordered ubiquitin-binding motif. Dreier JE, Prestel A, Martins JM, Brøndum SS, Nielsen O, Garbers AE, Suga H, Boomsma W, Rogers JM, Hartmann-Petersen R, Kragelund BB. Cell Mol Life Sci 79 484 (2022)
  234. A new mutation of BRCA2 gene in an Italian healthy woman with familial breast cancer history. Pisanò M, Mezzolla V, Galante MM, Alemanno G, Manca C, Lorusso V, Malvasi A, Tinelli A. Fam Cancer 10 65-71 (2011)
  235. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. Scully R, Xie A. J Mammary Gland Biol Neoplasia 9 237-246 (2004)
  236. BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination. Ghouil R, Miron S, Koornneef L, Veerman J, Paul MW, Le Du MH, Sleddens-Linkels E, van Rossum-Fikkert SE, van Loon Y, Felipe-Medina N, Pendas AM, Maas A, Essers J, Legrand P, Baarends WM, Kanaar R, Zinn-Justin S, Zelensky AN. Nat Commun 12 4605 (2021)
  237. BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks. Mishra AP, Hartford SA, Sahu S, Klarmann K, Chittela RK, Biswas K, Jeon AB, Martin BK, Burkett S, Southon E, Reid S, Albaugh ME, Karim B, Tessarollo L, Keller JR, Sharan SK. Nat Commun 13 1751 (2022)
  238. Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer. Nowacka-Zawisza M, Brys M, Romanowicz-Makowska H, Kulig A, Krajewska WM. Pathol Int 58 275-281 (2008)
  239. Genetic Variants in the 3'UTR of BRCA1 and BRCA2 Genes and their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer. Sánchez-Chaparro MM, Garza-Veloz I, Zayas-Villanueva OA, Martinez-Fierro ML, Delgado-Enciso I, Gomez-Govea MA, Martínez-de-Villarreal LE, Reséndez-Pérez D, Rodríguez-Sánchez IP. Diagnostics (Basel) 10 E298 (2020)
  240. Identification of the deleted in split hand/split foot 1 protein as a novel biomarker for human cervical cancer. Ma YY, Lin H, Chang FM, Chang TC, Trieu T, Pridgen HI, Zhang Y, Huang J, Patiño-Guzman K, Diab N, Cantu A, Slaga TJ, Wei SJ. Carcinogenesis 34 68-78 (2013)
  241. Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes. Ashton NW, Ashton NW, Loo D, Paquet N, O'Byrne KJ, Richard DJ. BMC Mol Biol 17 24 (2016)
  242. Rice OsBRCA2 Is Required for DNA Double-Strand Break Repair in Meiotic Cells. Fu R, Wang C, Shen H, Zhang J, Higgins JD, Liang W. Front Plant Sci 11 600820 (2020)
  243. ZFP281-BRCA2 prevents R-loop accumulation during DNA replication. Wang Y, Ma B, Liu X, Gao G, Che Z, Fan M, Meng S, Zhao X, Sugimura R, Cao H, Zhou Z, Xie J, Lin C, Luo Z. Nat Commun 13 3493 (2022)
  244. BRCA1/2 mutations are not a common cause of malignant melanoma in the Polish population. Dębniak T, Scott RJ, Górski B, Masojć B, Kram A, Maleszka R, Cybulski C, Paszkowska-Szczur K, Kashyap A, Murawa D, Malińska K, Kiedrowicz M, Rogoża-Janiszewska E, Rudnicka H, Deptuła J, Domagała P, Kluźniak W, Lener MR, Lubiński J. PLoS One 13 e0204768 (2018)
  245. Characterization of an SSB-dT25 complex: structural insights into the S-shaped ssDNA binding conformation. Huang YH, Chen IC, Huang CY. RSC Adv 9 40388-40396 (2019)
  246. DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation. Kwon Y, Rösner H, Zhao W, Selemenakis P, He Z, Kawale AS, Katz JN, Rogers CM, Neal FE, Badamchi Shabestari A, Petrosius V, Singh AK, Joel MZ, Lu L, Holloway SP, Burma S, Mukherjee B, Hromas R, Mazin A, Wiese C, Sørensen CS, Sung P. Nat Commun 14 432 (2023)
  247. Dss1 Regulates Association of Brh2 with Rad51. Zhou Q, Holloman WK. Biochemistry 56 3318-3327 (2017)
  248. Dual DNA-binding domains shape the interaction of Brh2 with DNA. Zhou Q, Holloman WK. DNA Repair (Amst) 22 104-111 (2014)
  249. Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Lee J, Sung K, Joo SY, Jeong JH, Kim SK, Lee H. Nat Commun 13 3396 (2022)
  250. GFP-Fragment Reassembly Screens for the Functional Characterization of Variants of Uncertain Significance in Protein Interaction Domains of the BRCA1 and BRCA2 Genes. Caleca L, Colombo M, van Overeem Hansen T, Lázaro C, Manoukian S, Parsons MT, Spurdle AB, Radice P. Cancers (Basel) 11 E151 (2019)
  251. Mutation analysis of the SHFM1 gene in breast/ovarian cancer families. Bonache S, de la Hoya M, Gutierrez-Enriquez S, Tenés A, Masas M, Balmaña J, Diez O. J Cancer Res Clin Oncol 139 529-532 (2013)
  252. The Inhibitory Effects and Cytotoxic Activities of the Stem Extract of Sarracenia purpurea against Melanoma Cells and the SsbA Protein. Liu HW, Chiang WY, Huang YH, Huang CY. Plants (Basel) 11 3164 (2022)
  253. Comment DNA repair: A protein giant in its entirety. Zou L. Nature 467 667-668 (2010)
  254. Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus. Park PG, Lee H. Exp Mol Med 40 339-344 (2008)
  255. Dissecting systems-wide data using mixture models: application to identify affected cellular processes. Svensson JP, de Menezes RX, Turesson I, Giphart-Gassler M, Vrieling H. BMC Bioinformatics 6 177 (2005)
  256. Early-onset breast cancer in a woman with a germline mobile element insertion resulting in BRCA2 disruption: a case report. Deuitch N, Li ST, Courtney E, Shaw T, Dent R, Tan V, Yackowski L, Torene R, Berkofsky-Fessler W, Ngeow J. Hum Genome Var 7 24 (2020)
  257. Epidemiological and ES cell-based functional evaluation of BRCA2 variants identified in families with breast cancer. Sullivan T, Thirthagiri E, Chong CE, Stauffer S, Reid S, Southon E, Hassan T, Ravichandran A, Wijaya E, Lim J, Taib NAM, Fadzli F, Yip CH, Hartman M, Li J, van Dam RM, North SL, Das R, Easton DF, Biswas K, Teo SH, Sharan SK, SGBCC Investigators, MYBRCA Investigators. Hum Mutat 42 200-212 (2021)
  258. Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben-Natan A, Pangilinan GR, Krishnappa N, Nielsen R, Hockemeyer D. Nat Biomed Eng (2023)
  259. Identification and purification of a soluble region in the breast cancer susceptibility protein BRCA2. Finch D, Webb M. Protein Expr Purif 40 177-182 (2005)
  260. Identification of a new complex deleterious mutation in exon 18 of the BRCA2 gene in a hereditary male/female breast cancer family. Diez O, Gutiérrez-Enríquez S, Masas M, Tenés A, Yagüe C, Arcusa A, Llort G. Breast Cancer Res Treat 123 587-590 (2010)
  261. Letter Mutations in the BRCA2 interacting DSS1 are not a risk factor for male breast cancer. Syrjäkoski K, Jäntti J, Kallioniemi A, Karhu R. Int J Cancer 120 444-446 (2007)
  262. BRCA2 c.8827C>T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer. Wang J, Qin J, Xi C, Zhang Y. Mol Genet Genomic Med 8 e1411 (2020)
  263. BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA. Bell JC, Dombrowski CC, Plank JL, Jensen RB, Kowalczykowski SC. Proc Natl Acad Sci U S A 120 e2221971120 (2023)
  264. Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay. Hu C, Susswein LR, Roberts ME, Yang H, Marshall ML, Hiraki S, Berkofsky-Fessler W, Gupta S, Shen W, Dunn CA, Huang H, Na J, Domchek SM, Yadav S, Monteiro ANA, Polley EC, Hart SN, Hruska KS, Couch FJ. Clin Cancer Res 28 3742-3751 (2022)
  265. Clinical consequences of BRCA2 hypomorphism. Castells-Roca L, Gutiérrez-Enríquez S, Bonache S, Bogliolo M, Carrasco E, Aza-Carmona M, Montalban G, Muñoz-Subirana N, Pujol R, Cruz C, Llop-Guevara A, Ramírez MJ, Saura C, Lasa A, Serra V, Diez O, Balmaña J, Surrallés J. NPJ Breast Cancer 7 117 (2021)
  266. DSSylation, a novel guide for protein degradation? Gong CX. Protein Cell 5 91-93 (2014)
  267. Intrinsically disordered protein AtDSS1(V) participates in plant defense response to oxidative stress. Nikolić IP, Nešić SB, Samardžić JT, Timotijević GS. Protoplasma 258 779-792 (2021)
  268. Mutant Brca2/p53 mice exhibit altered radiation responses in the developing mammary gland. Houle CD, Peddada SD, McAllister KA, Ward T, Malphurs J, Gersch WD, Davis BJ. Exp Toxicol Pathol 57 105-115 (2005)
  269. Mutational analysis of BRCA1 and BRCA2 in northwest Chinese breast cancer patients. Wang T, Zhang J, Xiao J, Huang M, Li N, Ling R. Transl Cancer Res 8 1845-1852 (2019)
  270. Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro. Jacobsen NL, Bloch M, Millard PS, Ruidiaz SF, Elsborg JD, Boomsma W, Hendus-Altenburger R, Hartmann-Petersen R, Kragelund BB. Protein Sci 32 e4733 (2023)
  271. Refinement of the assignment to the ACMG/AMP BS3 and PS3 criteria of eight BRCA1 variants of uncertain significance by integrating available functional data with protein interaction assays. Caleca L, Radice P. Front Oncol 13 1146604 (2023)
  272. Replication gap suppression depends on the double-strand DNA binding activity of BRCA2. Vugic D, Dumoulin I, Martin C, Minello A, Alvaro-Aranda L, Gomez-Escudero J, Chaaban R, Lebdy R, von Nicolai C, Boucherit V, Ribeyre C, Constantinou A, Carreira A. Nat Commun 14 446 (2023)
  273. Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing. Kuang Z, Ke J, Hong J, Zhu Z, Niu L. Nucleic Acids Res 50 8882-8897 (2022)
  274. Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Greenhough LA, Liang CC, Belan O, Kunzelmann S, Maslen S, Rodrigo-Brenni MC, Anand R, Skehel M, Boulton SJ, West SC. Nature 619 650-657 (2023)
  275. Subunit interface residues F129 and H294 of human RAD51 are essential for recombinase function. Amunugama R, Fishel R. PLoS One 6 e23071 (2011)
  276. THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans. Zheleva A, Camino LP, Fernández-Fernández N, García-Rubio M, Askjaer P, García-Muse T, Aguilera A. J Cell Sci 134 jcs258435 (2021)
  277. Template-based recognition of protein fold within the midnight and twilight zones of protein sequence similarity. Pirun M, Babnigg G, Stevens FJ. J Mol Recognit 18 203-212 (2005)
  278. The Novel Pathogenic Mutation c.849dupT in BRCA2 Contributes to the Nonsense-Mediated mRNA Decay of BRCA2 in Familial Breast Cancer. Li S, Ma J, Hu C, Zhang X, Xiao D, Hao L, Xia W, Yang J, Hu L, Liu X, Dong M, Ma D, Liu R. J Breast Cancer 21 330-333 (2018)
  279. Unexpected Findings in Hereditary Breast and Ovarian Cancer Syndrome: Low-Level Constitutional Mosaicism in BRCA2. Hidalgo Mayoral I, Almeida Santiago A, Sánchez-Zapardiel JM, Hidalgo Calero B, de la Hoya M, Gómez-Sanz A, de Miguel Reyes M, Robles L. Genes (Basel) 14 502 (2023)
  280. A Multiomics Signature Highlights Alterations Underlying Homologous Recombination Deficiency in Triple-Negative Breast Cancer. Su GH, Jiang L, Xiao Y, Zheng RC, Wang H, Jiang YZ, Peng WJ, Shao ZM, Gu YJ, You C. Ann Surg Oncol 29 7165-7175 (2022)
  281. A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin. Warren CR, Catts ZA, Farach-Carson MC. Exp Cell Res 317 2099-2109 (2011)
  282. Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast. Palihati M, Iwasaki H, Tsubouchi H. Life Sci Alliance 7 e202302342 (2024)
  283. Analyzing the effects of BRCA1/2 variants on mRNA splicing by minigene assay. Dong Z, Wang Y, Zhang J, Zhu F, Liu Z, Kang Y, Lin M, Shi H. J Hum Genet 68 65-71 (2023)
  284. BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair. Jimenez-Sainz J, Mathew J, Moore G, Lahiri S, Garbarino J, Eder JP, Rothenberg E, Jensen RB. Elife 11 e79183 (2022)
  285. CRISPR/Cas9-Targeted Disruption of Two Highly Homologous Arabidopsis thaliana DSS1 Genes with Roles in Development and the Oxidative Stress Response. Nikolić I, Samardžić J, Stevanović S, Miljuš-Đukić J, Milisavljević M, Timotijević G. Int J Mol Sci 24 2442 (2023)
  286. Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant. Mishra AP, Hartford S, Chittela RK, Sahu S, Kharat SS, Alvaro-Aranda L, Contreras-Perez A, Sullivan T, Martin BK, Albaugh M, Southon E, Burkett S, Karim B, Carreira A, Tessarollo L, Sharan SK. Cell Death Dis 14 753 (2023)
  287. Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil. Su HH, Huang YH, Lien Y, Yang PC, Huang CY. Int J Mol Sci 24 14899 (2023)
  288. News New breast cancer gene suggests a role for BRCA2 in sporadic cases. Devilee P. Eur J Hum Genet 12 257-258 (2004)
  289. New insights into the biological function of BRCA2 from its structural interactions. Waterworth A. Breast Cancer Res 5 107-108 (2003)
  290. Case Reports Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall. Algashaamy K, Tan Y, Mackrides N, Alencar A, Peng JH, Rosenblatt J, Alderuccio JP, Lossos IS, Vega F, Chapman J. Case Rep Hematol 2018 5761953 (2018)
  291. Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors. Bhat DS, Malacaria E, Biagi LD, Razzaghi M, Honda M, Hobbs KF, Hengel SR, Pichierri P, Spies MA, Spies M. NAR Cancer 5 zcad018 (2023)


Quick links