› 1ixx

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS

Released:
DOI: 10.2210/pdb1ixx/pdb
PDB entry 1ixx coloured by chain, front view.
PDB entry 1ixx coloured by chain, side view.
PDB entry 1ixx coloured by chain, top view.
Source organism: Protobothrops flavoviridis
Primary publication:
Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains.
Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T
Nat Struct Biol 4 438-41 (1997)
PMID: 9187649

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150062 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Snaclec coagulation factor IX/factor X-binding protein subunit A Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 129 amino acids
Theoretical weight: 14.85 KDa
Source organism: Protobothrops flavoviridis
UniProt:
  • Canonical: P23806 (Residues: 24-152; Coverage: 100%)
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A
Snaclec coagulation factor IX/factor X-binding protein subunit B Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 123 amino acids
Theoretical weight: 14.46 KDa
Source organism: Protobothrops flavoviridis
UniProt:
  • Canonical: P23807 (Residues: 24-146; Coverage: 100%)
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21212
Unit cell:
a: 172.2Å b: 85.7Å c: 65.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.221

Quick links

Citations

17 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
16 more

8 mentions without citation

Anticoagulant proteins from snake venoms: structure, function and mechanism.
Kini RM. (2006)
7 more